Disseminated Herpes Simplex Virus Type 2 after Treatment with Idelalisib
Journal Title: Biomedical Journal of Scientific & Technical Research (BJSTR) - Year 2019, Vol 14, Issue 3
Abstract
Introduction: Case reports describing disseminated Herpes simplex virus type 2 (HSV-2) disease are limited. To our knowledge, this is the first report of disseminated HSV-2 infection in a patient who was treated by idelalisib.Case: A 62-year-old female with chronic lymphocytic leukemia (CLL) presented with a painful pruritic rash. Her skin exam showed multiple erythematous papular lesions with central necrosis. Polymerase chain reaction in the peripheral blood and skin lesions was positive for HSV-2. The diagnosis of idelalisib-associated disseminated HSV-2 was made and the patient was started on IV acyclovir. On follow-up, her skin lesions completely resolved in six weeks. Idelalisib was stopped and the patient was started on venetoclax. Discussion: Idelalisib is a highly specific phosphatidylinositol 3-kinase delta (PI3Kδ) inhibitor that was approved by the FDA for the treatment of relapsed chronic lymphocytic leukemia, in combination with rituximab, relapsed follicular B-cell non-Hodgkin lymphoma, and in relapsed small lymphocytic lymphoma. This case highlights the potential cutaneous manifestation in immunocompromised individuals, which is often atypical and poses a difficulty in diagnosis. Physicians should consider HSV-2 as a rare but important cause of a disseminated rash in immunocompromised individuals. Antivirals including acyclovir and valacyclovir can successfully treat HSV-2 associated skin infection.
Authors and Affiliations
Joseph Attallah, Uqba Khan, Mamta Sharma, Zyad Kafri
Keywords
Related Articles
- EP ID EP585900
- DOI 10.26717/BJSTR.2019.14.002560
- Views 121
- Downloads 0
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