Dissolution Testing for Bioavailability of Over-the-Counter (OTC) Drugs—a Technical Note
Journal Title: AAPS PharmSciTech - Year 2015, Vol 16, Issue 5
Abstract
Thermoforma Orbital Shaker (420-4, Waltham, MA) was used to shake sample solutions at 100 RPM and 37°C. Orion pH Meter (710-1, Pittsburgh, PA) was used to measure solution pH. Two-point calibration with pH reference solution was performed before use of the pH meter. A Distek dissolution apparatus (2100A-2, North Brunswick, NJ) was used to conduct dissolution testing. For dissolution methods that require UV-Vis as the determinative step, an Agilent UV-Vis Spectrophotometer (8453-1, Santa Clara, CA) was used. For dissolution methods that require HPLC, an Agilent 1290 HPLC system with DAD detector was used.
Authors and Affiliations
Zongming Gao, Lawrence Yu, Stephanie Clark, Mike Trehy, Terry Moore, Benjamin Westenberger, Lucinda Buhse, John Kauffman, Benjamin Bishop, Lydia Velazquez, Scott Furness
Preparation and In Vitro–In Vivo Evaluation of Sustained-Release Matrix Pellets of Capsaicin to Enhance the Oral Bioavailability
Capsaicin has multiple pharmacological activities including antioxidant, anticancer, and anti-inflammatory activities. However, its clinical application is limited due to its poor aqueous solubility, gastric irritation,...
Influence of the Freeze-Drying Process on the Physicochemical and Biological Properties of Pre-heated Amphotericin B Micellar Systems
The moderate heat treatment of amphotericin B (AmB) in its micellar form (M-AmB) results in superaggregates (H-AmB) that present a substantially lower toxicity and similar activity. The aim of this work was to evaluate t...
Development and Characterization of Mixed Niosomes for Oral Delivery Using Candesartan Cilexetil as a Model Poorly Water-Soluble Drug
The aim of this study was to prepare candesartan cilexetil-loaded niosomes and mixed niosomes to enhance the aqueous solubility of the drug, thus improving its oral bioavailability. The formulations were prepared using v...
Nanodrug Delivery Systems: A Promising Technology for Detection, Diagnosis, and Treatment of Cancer
Nanotechnology has enabled the development of novel therapeutic and diagnostic strategies, such as advances in targeted drug delivery systems, versatile molecular imaging modalities, stimulus responsive components for fa...
New Method for Monitoring the Process of Freeze Drying of Biological Materials
A capacitive sensor was proposed and tested for the monitoring and control of a freeze drying process of a vaccine against the Newcastle disease of birds. The residual moisture of the vaccine was measured by the thermogr...