Dissolution Testing for Bioavailability of Over-the-Counter (OTC) Drugs—a Technical Note
Journal Title: AAPS PharmSciTech - Year 2015, Vol 16, Issue 5
Abstract
Thermoforma Orbital Shaker (420-4, Waltham, MA) was used to shake sample solutions at 100 RPM and 37°C. Orion pH Meter (710-1, Pittsburgh, PA) was used to measure solution pH. Two-point calibration with pH reference solution was performed before use of the pH meter. A Distek dissolution apparatus (2100A-2, North Brunswick, NJ) was used to conduct dissolution testing. For dissolution methods that require UV-Vis as the determinative step, an Agilent UV-Vis Spectrophotometer (8453-1, Santa Clara, CA) was used. For dissolution methods that require HPLC, an Agilent 1290 HPLC system with DAD detector was used.
Authors and Affiliations
Zongming Gao, Lawrence Yu, Stephanie Clark, Mike Trehy, Terry Moore, Benjamin Westenberger, Lucinda Buhse, John Kauffman, Benjamin Bishop, Lydia Velazquez, Scott Furness
Keywords
Related Articles
- EP ID EP682321
- DOI 10.1208/s12249-015-0297-x
- Views 80
- Downloads 0
Taste Masking of Griseofulvin and Caffeine Anhydrous Using Kleptose Linecaps DE17 by Hot Melt Extrusion
The objective of this project was to investigate the potential of Kleptose Linecaps DE17 (KLD) in masking the unpleasant/bitter taste of therapeutic agents by hot melt extrusion (HME). Griseofulvin (GRI) and caffeine anh...
Enhancement of Oral Bioavailability of Curcumin by a Novel Solid Dispersion System
The objective of this study was to improve the solubility and bioavailability of curcumin by a new curcumin dripping pills (Cur-DPs) formulation using melt mixing methods. The optimal formulation consisted of Polyethoxyl...
Eudragit L/HPMCAS Blend Enteric-Coated Lansoprazole Pellets: Enhanced Drug Stability and Oral Bioavailability
The online version of this article (doi:10.1208/s12249-013-0035-1) contains supplementary material, which is available to authorized users.
Injectable Supramolecular Hydrogel from Insulin-Loaded Triblock PCL-PEG-PCL Copolymer and γ-Cyclodextrin with Sustained-Release Property
Supramolecular hydrogels formed by cyclodextrins and polymers have been widely investigated as a biocompatible, biodegradable and controllable drug delivery system. In this study, a supramolecular hydrogel based on biode...
Dendrimer, Liposomes, Carbon Nanotubes and PLGA Nanoparticles: One Platform Assessment of Drug Delivery Potential
Liposomes (LIP), nanoparticles (NP), dendrimers (DEN), and carbon nanotubes (CNTs), represent eminent classes of drug delivery devices. A study was carried out herewith by employing docetaxel (DTX) as model drug to asses...