Distortion product otoacoustic emission levels and input/output-growth functions in normal-hearing individuals with tinnitus and/or hyperacusis
Journal Title: Otolaryngologia Polska - Year 2009, Vol 63, Issue 2
Abstract
The purpose of this study was to determine whether distortion product otoacoustic emissions (DPOAEs) can be used to distinguish among four groups with audiometrically normal-hearing sensitivity: (1) control adults without tinnitus or hyperacusis, (2) patients with tinnitus alone, (3) patients with hyperacusis alone, and (4) patients with both tinnitus and hyperacusis. Two types of DPOAE measures were evaluated: (1) the distortion product (DP-)gram measured with fi xed primary levels as a function of frequency, and (2) DPOAE input/output (I/O) functions for a range of primary levels between 45 and 70 dB sound pressure level (SPL) at 1000, 2000, and 4000 Hz. DP-grams did not clearly distinguish between the control and patient groups. There was, however, a consistent trend for the three patient groups to have decreased average DP levels at 4000 and 6000 Hz; this notch in the DP-gram was not observed in the response confi guration for the control group. In the three patient groups, 51 to 74% of these individuals had DP levels that were outside of the 95% confi dence range for the control group. The average slopes of the I/O growth functions for each of the patient groups were consistently steeper than those for the control group; however, the slope values were indistinguishable among the patient groups. About 60% of the patients’ DPOAE responses (in each group) were categorized as abnormal based on their slope values. Thus, DPOAE measures can be used with at least partial success to distinguish controls from patients with tinnitus, hyperacusis, or both tinnitus and hyperacusis, but not to discriminate among the respective patient groups. These fi ndings suggest that the pathology represented among the patient groups is consistent at the level of the cochlea; however, diagnostic tests targeted at higher centers of processing are needed if the individuals in these groups are to be distinguished among themselves. In all participants, DPOAEs with fi xed primary levels as a function of frequency were measured. There was a consistent trend for the three patient groups to have decreased average DP-gram levels at 4000 and 6000 Hz; this notch in the DP-gram was not observed in the response confi guration for the control group. In the three patient groups, 51 to 74% of these individuals had DP levels that were outside of the 95% confi dence range for the control group. Thus, DPOAE measures can be used with at least partial success to distinguish controls from patients with tinnitus, hyperacusis, or both tinnitus and hyperacusis, but not to discriminate among the respective patient groups. These fi ndings suggest that the pathology represented among the patient groups is consistent at the level of the cochlea; however, diagnostic tests targeted at higher centers of processing are needed if the individuals in these groups are to be distinguished among themselves.
Authors and Affiliations
Grażyna Bartnik, Monika Hawley, Marek Rogowski, Danuta Raj-Koziak, Anna Fabijanska, Craig Formby
Keywords
Related Articles
- EP ID EP51714
- DOI -
- Views 110
- Downloads 0
Molecularly targeted therapies in head and neck cancers
Head and neck cancers are 6th most common malignancies according to the incidence rate. Over 85% of tumors of this region are epithelial tumors, especially squamous cell carcinomas (head and neck squamous cell carcinomas...
Expression of activation antigens on the lymphocytes T in patients with carcinoma of the larynx and connection with tumor features
Introduction. Results of studies analyzing the role of immunocompetent cells in tumor environment and whole peripheral blood indicate their responsibility for aggressiveness of neoplasm, prognosis and therapeutic effect....
How useful is ultrasound in the assessment of local advancement of laryngeal cancer?
Aim: The aim of the presented study was to examine the possibility of assessing the advancement of laryngeal cancer by ultrasound (USG) in patients qualified for laryngectomy. Material and methods: Ultrasound examination...
Zasady leczenia niezłośliwych guzów krtani u chorych w wieku podeszłym – amyloidoza krtani
Introduction. Amyloidosis’ are the heterogeneous group of diseases characterized by extracellular accumulation of secondary protein structures causing progressive disturbances of the organs. Amyloid deposits are localize...
Guzy tylnego dołu czaszki jako przyczyna nagłego pogorszenia słuchu i/lub wystąpienia zawrotów głowy
SUMMARY Introduction: The aim of the work was to analyse sudden deterioration of hearing and/or vertigo occurrence as an early symptom of posterior cranial fossa tumours. Material and methods: Among 1.394 people who repo...