Distribution characteristics of unexpected antibody in 1 779 patients and corresponding blood transfusion strategy
Journal Title: Chinese Journal of Blood Transfusion - Year 2022, Vol 35, Issue 9
Abstract
Objective To observe the distribution of the unexpected antibodies in order to study the safety and strategies in 1 779 cases of clinical blood transfusion. Methods A total of 1 779 patients with unexpected antibodies were enrolled from transfusion candidates in various hospitals in Xi′an during a 10-year period(from 2012 to 2022.5). Results The unexpected antibodies were detected in 926(52.05%) of 1779 samples. The detected antibodies were mainly from 8 blood group systems and their distributions were as follows: Rh antibodies in 69.76%(646/926), Kidd in 2.59%(24/926), Lewis in 4.21%(39/926), MNS in 12.53%(116/926), P in 0.43%(4/926), Diego in 0.65%(6/926), Duffy in 0.54%(5/926), I in 0.97%(9/926), Rh+ MNS in 1.30%(12/926), Rh+ Lewis in 0.65%(6/926), Rh+ Kidd in 3.24%(30/926), Rh+ Diego in 1.51%(14/926), Rh+ Duffy in 0.86%(8/926), MNS+ Diego in 0.11%(1/926), Rh+ MNS+ Kidd in 0.22%(2/926), Rh+ Lewis+ Kidd in 0.22%(2/926), Rh+ Kidd+ P in 0.11%(1/926), Rh+ Kidd+ Diego in 0.11%(1/926). Conclusion According to the distribution of unexpected antibodies in Xi′an, antibodies from Rh system, were the most common ones.First, the production of unexpected antibodies can be effectively reduced by establishing Rh compatible blood transfusion. Secondly, antibody screen cells containing low-frequency antigens, such as Mur, Dia and Wra, should be reasonably selected to prevent missing detection of anti-low frequency antigen antibodies in Xi′an. Furthermore, the genotyping technology of rare blood group should be promoted and a rare blood group red blood cell bank be established to optimize the blood inventory and ensure the safety of blood transfusion.
Authors and Affiliations
Liangzi ZHANG, Qinqin ZUO, Yong ZHANG, Dazhou WU, Weiwei ZHANG, Hong WANG, Xiaoyue CHU, Juan MAO, Hua XU
Keywords
Related Articles
- EP ID EP738353
- DOI 10.13303/j.cjbt.issn.1004-549x.2022.09.019
- Views 59
- Downloads 1
Addressing blood safety implications of donors using HIV antiretroviral therapy
HIV infection and transmission is a serious threat to people's health and public health security. Antiretroviral therapy (ART), including pre-exposure prophylaxis (PrEP) and post-exposure prophylaxis (PEP), has played a...
Comparative study of the walk-in and appointment mode of apheresis platelets donation in Guangzhou
Objective To discuss the influence of apheresis platelets donation mode transformation, from walk-in to appointment, on apheresis platelets donation, donor retention and donation service quality. Methods The comparative...
Effects of APOBEC3G on the replications of severe fever with thrombocytopenia syndrome virus
Objective To study the effect of apolipoprotein B mRNA editing enzyme catalytic subunit 3G (APOBEC3G)on virus replication and IL-6 production during severe fever with thrombocytopenia syndrome virus (SFTSV) infection. Me...
Investigation on whole blood collection in Tianjin after fully lifting COVID-19 prevention and control measures
Objective To investigate the situation of whole blood collection in Tianjin after COVID-19 prevention and control measures were fully lifted. Methods The relevant data on whole blood collection of voluntary blood donors...
Annual financial expenditure in 24 domestic blood stations: a comparative analysis
Objective To study the annual financial expenditure in blood stations with different scales, and to establish the regression equation between blood collection units and total expenditure. Methods The annual total expendi...