Distribution of Multilayered Fiber Terminals in the Human Cerebellar Cortex. Visualization by Immunohistochemistry for Histamine
Journal Title: Online Journal of Neurology and Brain Disorders - Year 2019, Vol 2, Issue 3
Abstract
The distribution of histamine in the human cerebellar cortex was studied by light microscope immunohistochemistry using a rabbit polyclonal antibody anti-histamine. In all layers of the cerebellar cortex, were revealed punctate immunoreactive elements related to putative histaminergic nerve terminals. These findings provide insights into the existence of a histaminergic system in the human cerebellar cortex, presumably involved in the cerebrocerebellar circuit, the feedback circuit through which the cerebellum is widely connected with the neocortex and the hypothalamus and intervene in the regulation of motor and non-motor functions. Since Schmahmann and Sherman described a clinical syndrome, the cerebellar cognitive-affective syndrome, characterized by mental disorders and determined by cerebellar dysfunction [1], the cerebellum is considered to be involved also in the regulation of non-motor functions, including psychic functions, instinctive and emotional behaviors, and visceral activities [2]. The anatomical basis of these regulatory roles of the cerebellum is represented by the cerebrocerebellar circuit, a feedback circuit that bidirectionally connects the main superior cerebral centers and the cerebellum. Two main cerebrocerebellar circuit have been described, one established between neocortex and cerebellum, neocorticocerebellar circuit (NCC), one, between hypothalamus and cerebellum, hypothalamocerebellar circuit (HCC) [2].
Authors and Affiliations
Anna Rizzi, Matteo Saccia, Vincenzo Benagiano
Keywords
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- EP ID EP603498
- DOI 10.32474/OJNBD.2019.02.000139
- Views 70
- Downloads 0
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