DIURESIS: EXPERIMENTAL EVIDENCE OF POLYHERBALS IN ALBINO RATS
Journal Title: International Research Journal of Pharmacy (IRJP) - Year 2011, Vol 2, Issue 6
Abstract
Numerous medicinal plants and their formulations are used for various disorders in ethno medical practices as well in the traditional system of medicine in India. The Vrukkadoshantake vati (VV) and Nephrovin (NEP) are ayurvedic polyherbal formulations and are used in alternative system of medicine for treatment of urinary disorder. No data is available for its efficacious use in urinary disorders. The Lipschits method was used for collection of supportive data for diuretic action of the Vrukkadoshantake vati and Nephrovin. Wistar albino rats were fasted for 18 h prior to experiment and aqueous suspensions of the formulations were administered at the graded doses of 200, & 400mg/kg body weight. After the treatment, urine was collected for 24h and diuretic activity was assessed by evaluation of the total volume of urine, Na+, K+, Cl- concentration and also the Diuretic index, Nariuretic effect, & saluretic effect were calculated. The total urine volume of the rats treated with the aqueous suspensions of the formulations (400 mg/kg) were found to be nearly two fold (p<0.05) when compared with the control (saline treated) group. Excretion of cations (sodium and potassium ions) and anions (chloride ions) was also found to be increased significantly (p<0.01) with respect to the control group. The diuretic effect was comparable with that of the standard drug Furosemide.
Authors and Affiliations
Mukesh Kumawat , Mahesh Kamble , Dipak Gumate , Nilofar Naikwade , Prabha Mali
Keywords
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