DIURETIC ACTIVITY OF AQUEOUS DECOCTION EXTRACT AND ETHYL ACETATE FRACTION OF LANNEA MICROCARPA ENGL. AND K. KRAUSE (ANACARDIACEAE) TRUNK BARKS IN WISTAR RATS
Journal Title: World Journal of Pharmaceutical Research - Year 2018, Vol 7, Issue 12
Abstract
Medicinal plants are highly used in developing countries. In Burkina Faso, the Lannea microcarpa trunk barks extracts have been used for long time by the local community that evoked its various medicinal properties. However, no scientific evidence is hitherto available to support highlighted effects. To study the beneficial actions of Lannea microcarpa extracts as a cardiovascular and renal protective agent, we investigated the diuretic and saluretic properties of these extracts in normotensive rats. The experimental animals were divided into nine (09) groups of six (06) rats each. The rats were pretreated with isotonic saline (0.9% NaCl, 25 mL/kg body weight), to impose an uniform water and salt balance. Subsequently, different groups of rats were treated orally with LMaq or LMAE (10, 50 and 100 mg/kg), or furosemide (15 mg/kg) or amiloride (5 mg/kg). Rats urine were collected using a graduated and transparent tubes and its volume was measured at 2 h, 4 h, 6 h, 12 h and 24 h after starting experimentation. Cumulative urine excretion was calculated in relation to body weight and expressed as mL/100 g of body weight. The electrolytes Na+ and K+ concentrations were measured using an automate "Humalyte plus 3." Aqueous decoction showed a diuretic dose-dependent potential with respect to its ethyl acetate fraction. At a dose of 100 mg/kg LMaq, urinary excretion is more intense compared to control. Interestingly, the extracts eleminate Na+ while stabilizing the excretion of K+. Their mechanism of action was closer to furosemide than amiloride. Thus, Lannea microcarpa extracts could be benefit for the therapeutic management of cardiovascular and renal pathologies.
Authors and Affiliations
Nitiéma Mathieu
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