DNA CLEAVAGE POTENTIAL OF 4-(PIPERIDIN-1- YLMETHYL)-2-(THIOPHEN-2-YL) QUINOLINE ANALOGUES
Journal Title: Indo American Journal of Pharmaceutical Sciences - Year 2018, Vol 5, Issue 3
Abstract
DNA cleavage potential of 4-(piperidin-1-ylmethyl)-2-(thiophen-2-yl) quinoline 7(a-j) derivatives, were studied on Calf-thymus DNA by agarose gel electrophoresis method. The compounds 7e and 7j have exhibited almost complete cleavage, whereas the other compounds 7a, 7b, 7c, 7d, 7f, 7g and 7i have shown partial cleavage of DNA at 100 μg concentration. The compounds 7e and 7j can be considered as DNA intercalating agents due to its planarity and their potentiality to cleave the DNA completely. This might be through breaking the base pairs of DNA. Keywords: DNA, Calf-thymus DNA, Thiophene, Agarose gel electrophoresis.
Authors and Affiliations
Keywords
Related Articles
- EP ID EP277151
- DOI -
- Views 270
- Downloads 0
FORMULATION, EVALUATION AND OPTIMIZATION OF FLOATING MATRIX TABLETS OF CARVEDILOL
Bilayer floating tablets were prepared by direct compression using HPMC K100M and Ethyl cellulose as the release controlling polymers and sodium bicarbonate as a gas generating agent. The optimum concentrations of the ab...
ROLE OF SIMVASTATIN IN ADDITION TO METFORMIN IN POLYCYSTIC OVARIAN SYNDROME PATIENTS, A RANDOMIZED CONTROLLED TRIAL ON PAKISTANI WOMEN
Objective: To study the effect of using simvastatin in addition to metformin in treatment of polycystic ovarian syndrome (PCOS) and its comparison with metformin alone therapy. Methods: This is a randomized controlled tr...
SCREENING OF PHYTOCHEMICALS OF BLECHNUM ORIENTALE L. COLLECTED FROM KOTHIYAR, KANYAKUMARI DISTRICT, TAMIL NADU, INDIA
The aim of the present study was to screen the phytochemicals in the methanolic extract of Blechnum orientale L. collected from Kothiyar, located in Kanyakumari district, Tamil Nadu, India. The phytochemical screening of...
IN VITRO & IN VIVO ANTIOXIDANT AND HEPATOPROTECTIVE POTENTIAL OF CARALLUMA ADSCENDENS VAR. ATTENUATA AGAINST ETHANOL TOXICITY
Caralluma adscendens var. attenuata is a succulent plant grows in tropical areas. It has been reported for the presence of phenolics, flavanoids, tannins etc., which are responsible for antioxidant activity and hepatopro...
IN VITRO EVALUATION OF FEW METAL COMPOUNDS ON DROSOPHILA MELANOGASTER: A KEY FACTOR IN REDUCING FITNESS
Metals and metal ions play an important role in biological processes like growth, metabolism and other biochemical processes. In our present study, Drosophila melanogaster was used as a model organism to study the effect...