Do we Need New Therapies for Diabetes?
Journal Title: Diabetes Research – Open Journal - Year 2015, Vol 1, Issue 3
Abstract
Diabetes research and practice cluster (drug developers, payers, regulators and physicians) often (and especially in recent times) question the need of new therapies. Why would we need new therapies nowadays, when we have 9 classes (insulins, sulfonylureas, biguanides, meglitdes, thiazolidnediones, alpha-glucosidase inhibitors, DPP-4 inhibitors, SGLT2 inhibitors and GLP-1 receptor agonists),1 rapidly increasing number of biosimilars2 and uncountable number of generics? Reasonable question. Does it make sense to invest billions of dollars in messy global cardiovascular outcomes trials (as requested by diabetes drug development guidelines3 ) or to play love attraction games with payers4 so they “fall in love” with the “new” pill (most often combo with the good old metformin)?
Authors and Affiliations
Dimiter Dimitrov
Keywords
Related Articles
- EP ID EP550016
- DOI 10.17140/DROJ1-112
- Views 150
- Downloads 0
Glycemic Variations after Ingestion of Different Carbohydrate-Containing Foods Assessed by Continuous Glucose Monitoring in Healthy and Diabetic Individuals in Daily Life
Carbohydrate counting is a meal planning approach for diabetic patients, but individual variations of the effect of glycemic index do not seem to be well taken into account. Here we assessed glycemic variations after the...
Population-Based Strategy for Preventing Diabetes and its Complications
A recent report from the American College of Physicians (ACP) should cause a paradigm change for the treatment of diabetic patients.1 The main purpose of diabetes therapy is the prevention of complications.2 The endpoi...
Current Controversies around Carbohydrate Restriction and the Risk of High-Protein Diets
Recently, a Low carbohydrate (LCH) diet has been recommended by many doctors to control hyperglycemia and overweight. Unlike a traditional calorie-restricted diet, a carbohydrate-restricted diet typically contains less t...
An Overview of Diabetes and its Complications
Diabetes mellitus is a metabolic disorder in which the body’s capacity to utilise glucose, fat and protein is disturbed due to impairment in insulin secretion and/or insulin resistance leading to chronic hyperglycaemia....
Ketone Body Production and Excretion During Wellness Fasting
Introduction: The importance of ketone body metabolism in diabetic patients has been known since the 1970s, but recently β-hydroxybutyrate (βHB) has been identified as a key component of a metabolic signaling pathway. Ho...