Do we Need New Therapies for Diabetes?
Journal Title: Diabetes Research – Open Journal - Year 2015, Vol 1, Issue 3
Abstract
Diabetes research and practice cluster (drug developers, payers, regulators and physicians) often (and especially in recent times) question the need of new therapies. Why would we need new therapies nowadays, when we have 9 classes (insulins, sulfonylureas, biguanides, meglitdes, thiazolidnediones, alpha-glucosidase inhibitors, DPP-4 inhibitors, SGLT2 inhibitors and GLP-1 receptor agonists),1 rapidly increasing number of biosimilars2 and uncountable number of generics? Reasonable question. Does it make sense to invest billions of dollars in messy global cardiovascular outcomes trials (as requested by diabetes drug development guidelines3 ) or to play love attraction games with payers4 so they “fall in love” with the “new” pill (most often combo with the good old metformin)?
Authors and Affiliations
Dimiter Dimitrov
Keywords
Related Articles
- EP ID EP550016
- DOI 10.17140/DROJ1-112
- Views 142
- Downloads 0
Glycemic Variations after Ingestion of Different Carbohydrate-Containing Foods Assessed by Continuous Glucose Monitoring in Healthy and Diabetic Individuals in Daily Life
Carbohydrate counting is a meal planning approach for diabetic patients, but individual variations of the effect of glycemic index do not seem to be well taken into account. Here we assessed glycemic variations after the...
Intestinal Parasites in Diabetes Mellitus Patients in the Limbe and Buea Municipalities, Cameroon
Background: Intestinal parasites are an important cause of morbidity and mortality and a public health problem especially in tropical developing countries including Cameroon. The two main types of intestinal parasites ar...
Sleep and Diabetes in Adolescents: A Battle between Physiology and Social Factors
About 200,000 of individuals under 20 years of age have been diagnosed with diabetes. Many of them have type 1 diabetes (T1D) but type 2 diabetes (T2D), a disease that used to be seen primarily in adults over age 45, is...
Reduced Sampling Schedules for Calculation of an Insulin Sensitivity Index from the Liquid Meal Tolerance Test
Background: The objective of this study was to evaluate the performance of the Matsuda index of insulin sensitivity (MISI) calculated using reduced sampling schedules. Methods: Relationships between MISI values from a Li...
Diabetes in the Northwest Territories
An estimated 2.7 million (7.6%) Canadians were living with diabetes in 2012.1 Internationally, Canada has the fourth highest rate of diabetes, behind Mexico, the United States and Portugal.2 The prevalence of diabetes...