Docetaxel. Determination in workplace air with high performance liquid chromatography
Journal Title: Podstawy i Metody Oceny Środowiska Pracy - Year 2018, Vol 34, Issue 2
Abstract
Docetaxel (DCT) is a plant derived cytotoxic from taxane family - mitosis inhibitors. It is used in the treatment of breast, lung and prostate cancer, squamous cell carcinoma of the head and neck, and gastric adenoma. Docetaxel is a highly flammable liquid and health-threatening substance classified as mutagenicity category 2 and reproductive toxicity category 1B. This paper presents a method for measuring docetaxel in the workplace air with HPLC with diode array detector (DAD). The method is based on the adsorption of inhalable fraction of docetaxel aerosol on glass fiber filter, desorption with water and chromatographic analysis. The analysis was performed in reverse phase on C18 column and mobile phase – acetonitrile: ammonium acetate solution (45: 55). The measurement range was 0.6 – 10 µg/m3 for 480-L air sample. The limit of detection (LOD) was 0.0065 µg/ml and the limit of quantification (LOQ) was 0.0195 µg/ml. The developed method of docetaxel determination has been recorded as an analytical procedure (see appendix).<br/><br/>
Authors and Affiliations
Małgorzata Szewczyńska
Keywords
Related Articles
- EP ID EP346482
- DOI -
- Views 108
- Downloads 0
Pentachlorophenol. Determination in workplace air by means of high performance liquid chromatography
Pentachlorophenol (PCF) in room temperature is a crystalline solid with phenol-like odor. It is soluble in most organic solvents (diethyl ether, acetone, carbon tetrachloride, methanol). It is slightly soluble in water....
Chinolina. Dokumentacja proponowanych dopuszczalnych wielkości narażenia zawodowego
Chinolina (CAS Nr 91-22-5) jest bezbarwną cieczą o przenikliwym, nieprzyjemnym zapachu, która ciemnieje pod wpływem światła. Substancja rozpuszcza się w: alkoholu, eterze, acetonie oraz disiarczku węgla. Gwałtownie reagu...
Toluene diisocyanate. Determination of toluene diisocyanate isomers with high performance liquid chromatography
Toluene-2,4 and 2,6-diisocyanate (2,4-TDI; 2,6-TDI) are colorless to pale yellow liquids witha sharp acrid odor. 2,4-TDI and 2,6-TDI are two commonly used isomers of toluenediisocyanate(TDI). TDI mixture is most often us...
Harmonizacja strategii pomiarowych do oceny narażenia na: nanoobiekty, ich aglomeraty i agregaty (NOAA)
W artykule przedstawiono zagadnienia, które powinny być uwzględnione podczas harmonizacji metod pomiarów wykonywanych w rzeczywistych warunkach na stanowiskach pracy w kontekście oceny narażenia i ryzyka zawodowego oraz...
Cisplatin. Documentation of proposed values of occupational exposure limits (OELs)
Cisplatin is a cytostatic used in the treatment of testicular, ovarian, cervix and bladder cancers, squamous cell carcinoma of a head and a neck, small cell and non-small cell lung cancer. For medical staff, it is availa...