DOCKING AGAINST NOSOCOMIAL INFECTION-STAPHYLOCOCCUS EPIDERMIDIS
Journal Title: International Journal of Pharmacy and Pharmaceutical Sciences - Year 2014, Vol 6, Issue 10
Abstract
Objective: Nosocomial infections are acquired by immuno-compromised patients in hospitals which seem to be the serious health problem in recent times. Staphylococcus epidermidis, the commensal bacterium inhabiting human skin emerges as the most common opportunistic nosocomial pathogen due to its ability to form biofilms on medical devices. Biofilm acts as a mask against attacks from an immune system which leads in difficulty to eradicate. Several research works have been going on to find out the effective drug against hospital acquired infections since these pathogens are resistant to several antibiotics like methicillin, penicillin and amoxicillin. Using docking tools, an attempt has been made to find out the most potential drug against the nosocomial pathogen - Staphylococcus epidermidis. Methods: Using mcule online docking server, several drugs like linezolid, ceftaroline, rastomycin, vancomycin, nitrofurantoin, trimethoprim sulfamethoxazole, allicin and gallic acid were selected to dock against epidermin decarboxylase (Staphylococcus epidermidis).Results: Ceftaroline showed the lowest docking energy of -10.2 Kcal/mol against the target protein of Staphylococcus epidermidis (Table 1 and Figure 1) followed by Linezolid, Allcin and Rastomycin.Conclusion: By comparing the docking scores against the selected target, ceftaroline could be suggested as potential drug against coagulase negative Staphylococcus epidermidis infection.Â
Authors and Affiliations
Mrinalini Singh, S. Padmavathy
Keywords
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