Docking of human rhodopsin mutant (Gly90ÆAsp) with beta-arrestin and cyanidin 3-rutinoside to cure night blindness
Journal Title: Bioinformation - Year 2012, Vol 8, Issue 3
Abstract
Motivation: Rhodopsin is a visual pigment present in rod cells of retina. It belongs to GPCR family and involves photoisomerization of 11-cis-retinal to all-trans-retinal isomers, conformational changes in rhodopsin and signal transduction cascade to generate a nerve impulse. This signaling pathway has been targeted to eliminate the effect of a mutation (Gly90Asp) responsible for abnormal activation of G-protein without retinal conformations in the absence of light leading to congenital night blindness. A theoretical model of rhodopsin with induced mutation has been deliberated in order to find potential ligands which can offset this mutational effect. The binding interactions between the target mutated rhodopsin model and potential ligands have been predicted with the help of molecular docking. The results indicated strong functional benefits of ligands as an inhibitor and an agonist for mutated rhodopsin model. Therefore, we propose a new visual cascade model which can initiate the normal signaling of rhodopsin mutant with the help of proposed ligands and can provide a hope for vision in future.
Authors and Affiliations
Shagufta Kanwal, Sumaira Nishat , Muhammad Khan
Keywords
Related Articles
- EP ID EP124762
- DOI 10.6026/97320630008128
- Views 165
- Downloads 0
EGID: an ensemble algorithm for improved genomic island detection in genomic sequences
Genomicislands (GIs) are genomic regions that are originally transferred from other organisms. The detection of genomic islands in genomes can lead to many applications in industrial, medical and environmental contexts....
In silico modeling of ligand molecule for non structural 3 (NS3) protein target of flaviviruses
Flaviviruses are small, enveloped RNA viruses which cause a variety of diseases into animals and man. Despite the existence of licensed vaccines, yellow fever, Japanese encephalitis and tick-borne encephalitis also claim...
HPLC Retention time prediction for metabolome analysi.
Liquid Chromatography Time-of-Flight Mass Spectrometry (LC-TOF-MS) is widely used for profiling metabolite compounds. LC-TOF-MS is a chemical analysis technique that combines the physical separation capabilities of high-...
Phylogenetic analysis of chloroplast matK gene from Zingiberaceae for plant DNA barcoding.
MaturaseK gene (MatK) of chloroplast is highly conserved in plant systematics which is involved in Group II intron splicing. The size of the gene is 1500 bp in length, located with in the intron of trnK. In the present s...
Monozygotic twins: genes are not the destiny?
Monozygotic twins are considered to be genetically identical, yet can show high discordance in their phenotypes and disease susceptibility. Several studies have emphasized the influence of external factors and the role o...