Docking of human rhodopsin mutant (Gly90ÆAsp) with beta-arrestin and cyanidin 3-rutinoside to cure night blindness
Journal Title: Bioinformation - Year 2012, Vol 8, Issue 3
Abstract
Motivation: Rhodopsin is a visual pigment present in rod cells of retina. It belongs to GPCR family and involves photoisomerization of 11-cis-retinal to all-trans-retinal isomers, conformational changes in rhodopsin and signal transduction cascade to generate a nerve impulse. This signaling pathway has been targeted to eliminate the effect of a mutation (Gly90Asp) responsible for abnormal activation of G-protein without retinal conformations in the absence of light leading to congenital night blindness. A theoretical model of rhodopsin with induced mutation has been deliberated in order to find potential ligands which can offset this mutational effect. The binding interactions between the target mutated rhodopsin model and potential ligands have been predicted with the help of molecular docking. The results indicated strong functional benefits of ligands as an inhibitor and an agonist for mutated rhodopsin model. Therefore, we propose a new visual cascade model which can initiate the normal signaling of rhodopsin mutant with the help of proposed ligands and can provide a hope for vision in future.
Authors and Affiliations
Shagufta Kanwal, Sumaira Nishat , Muhammad Khan
Keywords
Related Articles
- EP ID EP124762
- DOI 10.6026/97320630008128
- Views 175
- Downloads 0
Recent trends in remote homology detection: an Indian Medley.
The development of remote homology detection methods is a challenging area in Bioinformatics. Sequence analysis-based approaches that address this problem have employed the use of profiles, templates and Hidden Markov Mo...
Schematic for efficient computation of GC, GC3, and AT3 bias spectra of genome
Selection of synonymous codons for an amino acid is biased in protein translation process. This biased selection causes repetition of synonymous codons in structural parts of genome that stands for high N/3 peaks in DNA...
HPLC Retention time prediction for metabolome analysi.
Liquid Chromatography Time-of-Flight Mass Spectrometry (LC-TOF-MS) is widely used for profiling metabolite compounds. LC-TOF-MS is a chemical analysis technique that combines the physical separation capabilities of high-...
Insights from molecular modeling and dynamics simulation of pathogen resistance (R) protein from brinjal.
Resistance (R) protein recognizes molecular signature of pathogen infection and activates downstream hypersensitive response signalling in plants. R protein works as a molecular switch for pathogen defence signalling and...
LIPPRED: A web server for accurate prediction of lipoprotein signal sequences and cleavage sites.
Bacterial lipoproteins have many important functions and represent a class of possible vaccine candidates. The prediction of lipoproteins from sequence is thus an important task for computational vaccinology. Naïve-Bayes...