DOCKING STUDIES ON SELECTED DENGUE AND RABIES VIRAL STRUCTURAL PROTEINS WITH CORIANDRUM SATIVUM L FLOWER CONSTITUENTS – AN IN SILICO APPROACH
Journal Title: World Journal of Pharmaceutical and life sciences - Year 2018, Vol 4, Issue 12
Abstract
Dengue virus contains two structural proteins and five non-structural proteins and Rabies virus contains three proteins structural and one non-structural protein, which are considered to be the most effective for drug designing. Recent studies have shown that these proteins can effectively cause the inactivation of dengue and rabies infection in humans. The entire parts of the plant Coriandrum sativum L like seeds, leaves, flower, fruits are found to have anti-oxidant and anti-mutagenic and anti-microbial properties. In this particular study, the binding efficiency of 7 compounds that are present in the Coriandrum sativum L with the selected structural proteins of Dengue virus and rabies virus were performed through Insilico methods. By our molecular docking result found that the hexadecanoic acid,methyl ester have highest binding affinity with the proteins.
Authors and Affiliations
Dr. Balasubramanian Sathyamurthy
Keywords
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