Docking study of the Rohitukine for the prevention of peptic ulcer- A New Target
Journal Title: The Journal of Phytopharmacology - Year 2014, Vol 3, Issue 1
Abstract
Context: In our previous study we have suggested that Rohitukine attenuates gastric mucosal injury; however its exact mechanism has not yet been established. Objective: The aim of present study was to evaluate the gastro protective mechanism of Rohitukine. Materials and methods: Sprague dawley rats and guinea pigs weighing 180–200 g were used. Dudenol ulcer was observed through Histamine induced gastric ulcer in guinea pigs. Result and Discussion: The present study was considered to evaluate the anti-ulcerogenic properties of an alkaloid chromane, Rohitukine from Dysoxylum binectariferum. Moreover, we studied the role of Rohitukine on the cytosolic concentration of cAMP and Histamine level in parietal cell-enriched cell suspension in order to ascertain its mechanism of action. In addition, Rohitukine failed to show protection in histamine induced gastric ulcer. Conclusion: Our docking study revealed that Rohitukine moderately bind with CCK2 receptor with binding energy as compare with standard drug benzotript. Furthermore, anti-secretory mechanism of Rohitukine mediated apparently through bind with CCK2 and inhibited the acid secretion, is novel to our finding.
Authors and Affiliations
Sunil Kumar Mishra, Vaibhav Mishra, Anil Kumar Pandey, Akanksha Srivastava, CKM Tripathi, Gautam Palit, Snober S. Mir, Abbas Ali Mahdi, Santosh Kumar Agarwal, Vijai Lakshmi
Keywords
Related Articles
- EP ID EP49539
- DOI -
- Views 215
- Downloads 0
Preliminary Phytochemical Analysis of Leaf and Bark methanolic extract of Sesbania grandiflora
Sesbania grandiflora L. (family- Leguminosae) is a small erect, fast-growing, and sparsely branched tree that reaches 10 m in height. The bark of this species is light gray, corky and deeply furrowed and the wood is so...
Quality control constraint of Guizotia abyssinica Cass, source of medicinally useful edible oil seeds
Introduction: Guizotia abyssinica Cass. branched herb with erect, stout stem, commonly known as Ramtil or Niger seed. Seeds are the rich source of oil with high nutritional index. Traditionally the seed powder is used a...
Isolation and identification of euphol and β-sitosterol from the dichloromethane extracts of Synadenium glaucescens
Purification of dichloromethane extract from root barks and leaves of Synadenium glaucescens respectively resulted into the isolation of two compounds namely Euphol and β-sitosterol. Chemical structures were establishe...
Pharmacognostical and Phytochemical Evaluation of Pilla Shukra Nashaka Anjana Varti: An ocular Ayurvedic Formulations
Pilla Shukra Nashaka Anjana Varti is an important Ayurvedic formulation containing Haritaki (Terminalia chebula Retz.), Amalaki (Emblica officinalis Gaertn.), Bibhitaki (Terminalia bellerica Roxb.), Katuki (Picrohriza...
Anticonvulsant, Anthelmintic and Antibacterial activity of Lawsonia inermis
Lawsonia inermis L. is a branched glabrous shrub or small tree, cultivated for its leaves although stem bark, roots, flowers and seeds have also been used in traditional medicine. In the present study anticonvulsant, a...