Does central IL-1β affect GnRH secretion in the hypothalamus of anoestrous ewes via different regulatory pathways?
Journal Title: Journal of Animal and Feed Sciences - Year 2013, Vol 22, Issue 1
Abstract
The study was designed to identify the central pathways through which central interleukin-1β (IL-1β) affects gonadotropin-releasing hormone (GnRH) release in anoestrous ewes. Our results show that intracerebroventricular (icv.) injection of IL-1β (50 μg) decreases the GnRH concentration in the perfusates collected from the medial basal hypothalamus/median eminence (MBH/ME), increases its type I receptor gene expression in the preoptic area, anterior hypothalamus (AHA) and medial basal hypothalamus, and significantly decreases the neuropeptide Y (NPY) mRNA level in the AHA and MBH. No effect of IL-1β treatment was found on plasma cortisol concentration, catecholamine (norepinephrine and dopamine) levels in perfusates, as well as cyclooxygenase-1 (COX-1) and cyclooxygenase-2 (COX-2) gene expression in the hypothalamus. Our data demonstrate that central IL-1β suppresses GnRH release mainly by acting directly through its own hypothalamic receptors, and its effect could be, at least partially, caused by changes in the NPY level, which is known as an important modulator of GnRH biosynthesis and release.
Authors and Affiliations
Dorota Tomaszewska-Zaremba, Andrzej Przemysław Herman, Tomasz Misztal
Keywords
Related Articles
- EP ID EP72902
- DOI -
- Views 116
- Downloads 0
A rapid HPLC method for the determination of sulphonamides and trimethoprim in feed premixes
simple HPLC method for the simultaneous determination of sulphadimidine, sulphadiazine, sulphamethoxazole and trimethoprim antibiotics in medicated feeds has been developed, validated, and applied to commercial feed prem...
Modeling lactation curves of Polish Holstein-Friesian cows. Part II: Prediction of 305-d lactation milk, fat and protein yields
The objective of the study was to compare five lactation curve models, Ali and Schaeffer, Guo, Wilmink, and third- and fourth-order normalized Legendre polynomials, for their ability to reliably predict 305-d lactation y...
Administration of Lactobacillus fermentum I5007 to young piglets improved their health and growth
The study determined the effects of Lactobacillus fermentum I5007 administered early in the life of piglets on their growth, faecal microflora, immune index and antioxidant activity. Twelve litters of 3-day-old crossbree...
Aspects of appropriate feeding of cows for production of milk enriched in the fatty acids, EPA and DHA. A review
Eicosapentaenoic (EPA) and docosahexaenoic (DHA) acids are long-chain n-3 polyunsaturated fatty acids that are essential for human health. They play an important role in prevention of heart disease and some cancers. The...
The effect of intracerebroventricular infusions of ghrelin on the secretory activity of the GnRH/LH system in peripubertal ewes
Ghrelin is a 28-amino acid orexigenic peptide, synthesized mainly by cells located in the stomach mucosa, that can be also engaged in modulation of reproductive functions. The aim of this study was to investigate the eff...