Does it need to Take Digitally Targeted Biopsies Additionally to TRUS Guided 12- Core Systematic Prostate Biopsies? A Single Center Prospective Clinical Study
Journal Title: Open Access Journal of Urology & Nephrology - Year 2019, Vol 4, Issue 1
Abstract
Purpose: To investigate whether digitally targeted additional biopsies enhance the detection rate of standard 12-core TRUS guided systematic biopsies. Methods: A total of 119 patients who either have a PSA level greater than 4ng/ml or suspicious DRE regardless of their PSA level underwent a twelve cores TRUS guided standard systematic prostate biopsies and two additional DRE guided targeted biopsies in case of abnormal DRE. The patients were divided into three groups with regards to their PSA level; Group I (n=8): PSA<4ng/ml, Group II (n=62): PSA 4-10ng/ml and Group III (n=49): PSA>10ng/ml. In each group, the independent diagnostic yield of DRE guided biopsies was compared to the standard systematic biopsies. The Results: Group I: In 3 out of 8 patients in this group were diagnosed as poorly differentiated prostate cancer. DRE guided biopsies detected one cancer out of 2 in this group. Group II: TRUSG guided systematic biopsies revealed 6 prostate cancer out of 7 cancer cases. DRE guided biopsies were also positive for prostate cancer in only 1 case, while standard 12-core systematic biopsies had failed to depict the cancer. Group III: Both TRUSG guided systematic biopsies and DRE guided biopsies revealed prostate cancer in all 17 cases. DRE guided biopsies did not increase the detection rate of systematic biopsies in this group. Conclusion: Digitally guided biopsies additionally taken to systematic 12-core biopsies do not enhance the detection rate of prostate cancer in the patients with a PSA level greater than 20ng/ml, possibly due to a large volume disease, however, it may be a useful adjunct for the patients with a PSA level less than 10ng/ml as well as in the presence of undifferentiated tumors.
Authors and Affiliations
Sarp Korcan Keskin
Keywords
Related Articles
- EP ID EP516002
- DOI -
- Views 55
- Downloads 0
The Importance of Urinary Tract Infections (Utis)
Urinary Tract Infections (UTIs) are significant infectious diseases which may infect different parts of the urinary tract. The UTIs clinical demonstrations involve a variety of signs and symptoms. The level, severity and...
Long-Term Clean Intermittent Catheterization, Chronic Inflammation and Cancer: A Case Report and Review
In areas not endemic for schistosomiasis, the development of squamous cell carcinoma of the bladder (bSCC) is commonly associated with long-term indwelling catheterization (LTIC) and its associated bladder inflammation....
Bladder Outlet Obstruction Due to Bladder Leiomyoma – Case Report and Literature Review
Bladder Leiomyoma is a rare and benign disease with a variable clinical presentation. The use of imaging exams is necessary for both diagnostic confirmation and therapeutic programming. The objective of this work was to...
Future Perspectives, Education and Training of Flexible Ureteroscopy for Urolithiasis-Some Personal Views
Urolithiasis is a common problem affecting patients irrespective of age and gender. Importantly, it is a recurrent disease with a lifetime risk of recurrencureteroscopygh. In the present days, almost all urinary tract st...
Urological Presentation in Zika Virus Infection: A Forgotten Issue
Zika virus infection is an important problem at present. The clinical presentation of Zika virus infection is usually mild or asymptomatic but it can also induce the neurological complication and teratogenic problem. In...