Does midazolam affect postoperative nausea and vomiting?
Journal Title: Ege Tıp Dergisi - Year 2014, Vol 53, Issue 4
Abstract
Aim: Postoperative nausea and vomiting (PONV) is one of the complications in a prolonged length of stay in postoperative care unit and hospital and thus, affects postoperative morbidity. We aimed to compare the effects of intraoperative midazolam and ondansetron on PONV. Materials and Methods: Upon obtaining ethical committee consent, 60 patients (ASA I-II) agreed to participate in the randomized, prospective and double-blinded study for elective thyroid and parathyroid surgery were enrolled. Following removal of thyroid / parathyroid tissue the patients in Group M were administered midazolam IV 2 mg, and the patients in Group O were administered ondansetron IV 4 mg. Thirty minutes before the end of surgery the patients were given paracetamol. The duration of anesthesia and surgery, wake-up time, time until Aldrete score reached 10, nausea and vomiting frequency, OAS/S and VAS scores additional antiemetic need were recorded for 24 hours. Results: There were no differences between the two groups with respect to demographic parameters. However, the operation time for Group O was longer. The total amount of fentanyl used, wake-up time, and the need for additional antiemetics in the two groups were not significantly different. The time until Aldrete score reached was significantly longer in Group M than in Group O. (p<0.05). The vomiting frequency was higher in Group M than in Group O at the 24th hour (p=0.005). Conclusion: In this study where the effects of midazolam and ondansetron on PONV were compared, it was determined that sedation achieved with midalozam may be effective in the early postoperative period.
Authors and Affiliations
A Öztaş, E Erkılıç, T Gümüş, O Kanbak
Keywords
Related Articles
- EP ID EP348892
- DOI 10.19161/etd.344087
- Views 102
- Downloads 0
Isolation of recombinant Crimean-Congo hemorrhagic fever virus nucleoprotein and its usage in ELISA
Aim: In this study, we aimed to develop an ELISA (Enzyme-Linked Immuno Sorbent Assay) kit to determine specific CCHFV (Crimean-Congo Hemorrhagic Fever Virus) immunoglobulins in serum samples from patients. Materials and...
Pregabaline effect on visual analog scale values after lumbar inter-laminar epidural corticosteroid injection
Aim: Inter-laminar lumbar epidural corticosteroid injection (ILECI) is a minimally invasive treatment method that is used in low-back pain. In this study, we aimed at investigating the effect of pregabalin administration...
Intracellular trafficking and cell behaviour characteristics
Cell behavior, differentiation and cell division pattern is vital for living organisms. Cellular differentiation and diversification is directly and indirectly affected by cell skeleton, cell polarity, intracellular and...
A case of dermatomyositis with a dramatic response to IVIG treatment
Dermatomiyozitis (DM) is an idiopathic inflammatory myopathy and a rare connective tissue disease which is characterized by skin lesions. Diagnosis of DM requires a characteristic rash and other criteria, such as proxima...
Primary carcinoid tumor of the kidney
Primary renal carcinoid tumor is an exceedingly rare neoplasm which was first reported by Rensick et al. in 1966. In a recent comprehensive review of the literature, Murali et al. and Romero et al. reviewed the literatur...