Does midazolam affect postoperative nausea and vomiting?
Journal Title: Ege Tıp Dergisi - Year 2014, Vol 53, Issue 4
Abstract
Aim: Postoperative nausea and vomiting (PONV) is one of the complications in a prolonged length of stay in postoperative care unit and hospital and thus, affects postoperative morbidity. We aimed to compare the effects of intraoperative midazolam and ondansetron on PONV. Materials and Methods: Upon obtaining ethical committee consent, 60 patients (ASA I-II) agreed to participate in the randomized, prospective and double-blinded study for elective thyroid and parathyroid surgery were enrolled. Following removal of thyroid / parathyroid tissue the patients in Group M were administered midazolam IV 2 mg, and the patients in Group O were administered ondansetron IV 4 mg. Thirty minutes before the end of surgery the patients were given paracetamol. The duration of anesthesia and surgery, wake-up time, time until Aldrete score reached 10, nausea and vomiting frequency, OAS/S and VAS scores additional antiemetic need were recorded for 24 hours. Results: There were no differences between the two groups with respect to demographic parameters. However, the operation time for Group O was longer. The total amount of fentanyl used, wake-up time, and the need for additional antiemetics in the two groups were not significantly different. The time until Aldrete score reached was significantly longer in Group M than in Group O. (p<0.05). The vomiting frequency was higher in Group M than in Group O at the 24th hour (p=0.005). Conclusion: In this study where the effects of midazolam and ondansetron on PONV were compared, it was determined that sedation achieved with midalozam may be effective in the early postoperative period.
Authors and Affiliations
A Öztaş, E Erkılıç, T Gümüş, O Kanbak
Keywords
Related Articles
- EP ID EP348892
- DOI 10.19161/etd.344087
- Views 105
- Downloads 0
Left pulmonary artery obstruction due to a large congenital thymic cyst: A rare cause of pulmonary stenosis
Thymic cysts occur relatively rarely and account for only about 3% of all anterior mediastinal masses. They may be either congenital or acquired. They usually present in the first decade after the age of 2 years, possibl...
Surgical treatment of ebstein anomaly: A unicenter experience
Aim: Ebstein anomaly is a rare congenital cardiac disorder that causing by failure of delamination of the tricuspid valve. Various surgical methods have been developed so far as treatment options. Our initial experience...
Non-Alkolik nedenlere bağlı gelişen wernicke ensefalopatisinde manyetik rezonans görüntüleme bulguları
Amaç: Wernicke ensefalopatisi (WE) tiamin (vitamin B1) eksikliğine bağlı olarak gelişen nöropsikiyatrik bir hastalıktır. Sıklıkla kronik alkolizme bağlı olarak görülmekle birlikte tiamin alım veya emilim eksikliğine nede...
Would a laboratory designed HBV DNA quantification protocol be appropriate for routine use? – Ege University Clinical Virology Laboratory's experience
Aim: Hepatitis B virus (HBV) DNA quantification is an important indicator during the follow-up of chronic hepatitis B infection, which has a major public health impact in Turkey due to its hepatocellular carcinoma and fa...
Anti-TNF tedavi seyrinde gelişen otoimmün hastalıklar: Eşlik eden hastalık mı? İlaca mı bağlı?
Anti-TNF tedavilerin romatolojik ve otoimmün hastalıkların tedavisinde yaygın kullanımı ve uzun dönem takipleri ile birlikte, paradoksal olarak anti-TNF ilişkili otoimmün hastalıklarla ilgili artan sayıda bildiriler olma...