Does Ozone Administration Have a Protective Effect Against Cisplatininduced Histological Changes in Rat Testis?
Journal Title: JOURNAL OF UROLOGICAL SURGERY - Year 2019, Vol 6, Issue 1
Abstract
Objective: We investigated the protective and therapeutic effects of ozone therapy (OT) on cisplatin (CP)-induced testicular damage. Materials and Methods: Thirty healthy adult male Wistar rats were divided into five groups consisting of 6 animals each: 1) control, 2) CP, 3) OT, 4) OT + CP and 5) CP + OT groups. Histopathological findings, Johnsen scores, thiobarbituric acid-reactive substances (TBARS), glutathione (GSH), superoxide dismutase (SOD), catalase, and GSH peroxidase (GPx) levels were evaluated. Results: CP caused a significant decrease in testicular weight and Johnsen score compared to the control group. In addition, TBARS level was significantly higher, whereas GSH, SOD, catalase and GPx levels were significantly lower in the CP group when compared to the control group. Pre- and post-CP OT significantly increased GSH, SOD, catalase and GPx levels and decreased TBARS level. Also, testicular weight and Johnsen score were increased with OT. Conclusion: The present study showed that OT is protective against CP-induced testicular damage. OT may be beneficial to patients who underwent CP chemotherapy.
Authors and Affiliations
İbrahim Aydoğdu, Rahmi Gökhan Ekin, Pelin Yıldız, Semih Lütfi Mirapoğlu, Ali Çay, Yaren Ece Aydoğdu, Hüseyin Kılınçaslan, Mehmet Bülent Semerci, Yusuf Özlem İlbey
Keywords
Related Articles
- EP ID EP550540
- DOI 10.4274/jus.galenos.2018.2225
- Views 73
- Downloads 0
Re: Effects of Recurrent Urinary Tract Infections on Graft and Patient Outcomes After Kidney Transplantation
.
Publication Rates and Citation Analysis of Oral and Poster Presentations at the First Congress of the Society of Urological Surgery in Turkiye
Objective: Publications of congress presentations (oral/poster) contribute to the literature by creating new information. In this study, we examined the publication rate of poster and oral presentations at the 1st Congre...
Long-term Results of Patients with Testicular Tumors Undergoing Testis Sparing Surgery: A Single-center Experience
Objective: To determine the clinicopathologic and oncologic outcomes of testis-sparing surgery (TSS) by evaluating the data of patients who underwent TSS in our clinic. Materials and Methods: A total of 24 patients (27 t...
Male Infertility as A Window to Health
Male factor infertility thought to affect approximately 50% of infertile couples worldwide. In the literature, there is a growing body of evidence that suggest associations between male infertility and other medical cond...
Utility of Flexible Ureterorenoscopy and Laser Lithotripsy in the Treatment of Multiple Intrarenal Stones
Objective: We aimed to determine the safety and efficacy of flexible ureterorenoscopy and Holmium laser lithotripsy in treating multiple intrarenal stones. Materials and Methods: We identified 32 consecutive patients wit...