Does Ozone Administration Have a Protective Effect Against Cisplatininduced Histological Changes in Rat Testis?
Journal Title: JOURNAL OF UROLOGICAL SURGERY - Year 2019, Vol 6, Issue 1
Abstract
Objective: We investigated the protective and therapeutic effects of ozone therapy (OT) on cisplatin (CP)-induced testicular damage. Materials and Methods: Thirty healthy adult male Wistar rats were divided into five groups consisting of 6 animals each: 1) control, 2) CP, 3) OT, 4) OT + CP and 5) CP + OT groups. Histopathological findings, Johnsen scores, thiobarbituric acid-reactive substances (TBARS), glutathione (GSH), superoxide dismutase (SOD), catalase, and GSH peroxidase (GPx) levels were evaluated. Results: CP caused a significant decrease in testicular weight and Johnsen score compared to the control group. In addition, TBARS level was significantly higher, whereas GSH, SOD, catalase and GPx levels were significantly lower in the CP group when compared to the control group. Pre- and post-CP OT significantly increased GSH, SOD, catalase and GPx levels and decreased TBARS level. Also, testicular weight and Johnsen score were increased with OT. Conclusion: The present study showed that OT is protective against CP-induced testicular damage. OT may be beneficial to patients who underwent CP chemotherapy.
Authors and Affiliations
İbrahim Aydoğdu, Rahmi Gökhan Ekin, Pelin Yıldız, Semih Lütfi Mirapoğlu, Ali Çay, Yaren Ece Aydoğdu, Hüseyin Kılınçaslan, Mehmet Bülent Semerci, Yusuf Özlem İlbey
Keywords
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- DOI 10.4274/jus.galenos.2018.2225
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