Does Serum Testosterone Levels in Postmenopausal Women Have An Effect on Developing Carcinoma Breast: A Case Control Study
Journal Title: IOSR Journal of Dental and Medical Sciences (IOSR-JDMS) - Year 2019, Vol 18, Issue 3
Abstract
Large prospective cohort studies have shown that high levels of oestrogen in postmenopausal women increases mammary proliferation and is associated with an increased risk of developing breast carcinoma. However, there is conflicting evidence between the association of circulating androgen levels and breast carcinoma. Some studies show elevated levels of androgens (and oestrogens) to be associated with increased risk of breast cancer. Others show that androgens act with protective patterns. Finally, there are some studies that observe no association between serum concentrations of androgens and breast cancer risk.We aim to investigate whether the serum testosterone levels of postmenopausal women diagnosed to have carcinoma breast are lower than that of the women who do not manifest this diagnosis. This was a single centre casecontrol study conducted from January 2017 to June 2018. One-point blood samples were collected and tested for serum testosterone levels by Chemiluminescence method. Data was analysed with a confidence interval of 95% and power of study at 80%. A total of 118 patients were included in the study, 59 postmenopausal women newly diagnosed to have carcinoma breast and 59 control subjects. Ages of the study population ranged from 45 to 85 years, the mean age of patients in the case and control groups were 55.15 ± 8.4 years and 61.59 ± 8.7 years (p = 0.00). Serum testosterone levels in the case group were significantly lower by nearly 50 percent when compared to the control populations, mean levels were 0.079ng/ml in cases and 0.159ng/ml in the control group (p = 0.009). We conclude that higher testosterone levels may adopt a protective role by reducing the proliferative effects of oestrogens on the mammary tissue and by possibly inhibiting the development of carcinogenesis in mammary tissue.
Authors and Affiliations
Akhil Hazari, Rajashekar Mohan
Keywords
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- EP ID EP557220
- DOI 10.9790/0853-1803122633.
- Views 59
- Downloads 0
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