Does the Addition of Melatonin to Quadruple Therapy Increases the Eradication Rate of Helicobacter pylori? A Double-Blind Randomized Clinical Trial
Journal Title: Journal of Clinical and Diagnostic Research - Year 2018, Vol 12, Issue 5
Abstract
ABSTRACT Introduction: The failure in eradication of Helicobacter pylori (H.pylori) using standard treatments is a common concern all over the world. Limited data have shown efficacy of melatonin against H.pylori in vitro. We hypothesise that, melatonin as adjuvant to quadruple therapy may improve H.pylori eradication rate. Aim: To evaluate additive effects of melatonin combined with a quadruple therapy for the eradication of H.pylori. Materials and Methods: This was a double-blind, placebo-controlled, randomized clinical trial. The trial comprised a 14-days, quadruple eradication regimen (omeprazole 20 mg twice daily; bismuth subsalicylate 525 mg four times daily; amoxicillin 1000 mg twice daily; and metronidazole 500 mg twice daily) supplemented with melatonin 3 mg/d (MEL group) or a comparable placebo (placebo group) without melatonin. The data were analysed using the SPSS version 19 and p-values less than 0.05 was considered statistically significant. Results: Eradication rates of intention-to-treat analysis (ITT; n = 118) were 73% in the MEL group and 65% in the placebo group. Eradication rates of per protocol analysis (PP; n = 98) were 80% and 79% in the MEL and placebo groups, respectively. There was no significant difference between the two groups either by ITT or PP analysis (p = 0.74 and p = 0.91, respectively). Conclusion: According to the result of the trial, MEL 3 mg/d does not have an additive effect on the eradication of H.pylori infection.
Authors and Affiliations
Saeed Abdi, Mohammad Abbasinazari, Ghasem Valizadegan, Mahdieh Kamarei, Yunes Panahi, Farhad Sarafzadeh, Mohammad Amin Pourhoseingholi
Keywords
Related Articles
- EP ID EP522645
- DOI 10.7860/JCDR/2018/35589.11543
- Views 50
- Downloads 0
Significance of Foetal Transcerebellar Diameter in Foetal Biometry: A Pilot Study
Introduction: The most important parameter needed for appropriate management of pregnant women is accurate Gestational Age (GA). Routine sonographic estimation of GA by using Biparietal Diameter (BPD), Femur Length (FL),...
Histochemical Study of Inflammatory Lesions of Gall Bladder with Reference to Metaplastic Conditions
ABSTRACT Introduction: Cholelithiasis and asymptomatic gallstones may produce pathological changes like hyperplasia and metaplasia of the gall bladder mucosal epithelium. It has been suggested that metaplastic epitheliu...
Er:YAG and Diode Lasers in Treatment of Peri-Implantitis–A Case Report
ABSTRACT One of the leading causes of dental implant loss in the present time is peri-implantitis. This paper describes a clinical case of peri-implantitis treatment using Er:YAG and a 980-nm diode laser. In the present...
Expression of Angiogenic Factors in Psoriasis Vulgaris
Introduction: Psoriasis is a chronic inflammatory skin disease characterized by epidermal hyperproliferation, abnormal differentiation and inflammatory infiltration in the dermis. The dermal microvascular expansion assoc...
Comparing the Ease of Insertion and Haemodynamic changes of Laryngeal Mask Airway and Combitube in Patients undergoing General Anaesthesia
ABSTRACT Introduction: Laryngeal Mask Airway (LMA) and combitube are used as an alternative to endotracheal tube for airway maintenance and in elective surgeries whenever required. Aim: To compare the ease of insertion...