Does the Systemic Plasma Profile Inform the Liver Profile? Analysis Using a Physiologically Based Pharmacokinetic Model and Individual Compounds
Journal Title: The AAPS Journal - Year 2016, Vol 18, Issue 3
Abstract
The online version of this article (doi:10.1208/s12248-016-9895-0) contains supplementary material, which is available to authorized users.
Authors and Affiliations
Rui Li, Tristan S. Maurer, Kevin Sweeney, Hugh A. Barton
Keywords
Related Articles
- EP ID EP680882
- DOI 10.1208/s12248-016-9895-0
- Views 95
- Downloads 0
Conformational Analysis of Therapeutic Proteins by Hydroxyl Radical Protein Footprinting
The online version of this article (doi:10.1208/s12248-012-9336-7) contains supplementary material, which is available to authorized users.
Mechanistic Pharmacokinetic/Target Engagement/Pharmacodynamic (PK/TE/PD) Modeling in Deciphering Interplay Between a Monoclonal Antibody and Its Soluble Target in Cynomolgus Monkeys
The online version of this article (doi:10.1208/s12248-013-9545-8) contains supplementary material, which is available to authorized users.
International Guidelines for Bioequivalence of Systemically Available Orally Administered Generic Drug Products: A Survey of Similarities and Differences
The objective of this article is to discuss the similarities and differences among bioequivalence approaches used by international regulatory authorities when reviewing applications for marketing new generic drug product...
Effect of Ethanol on Opioid Drug Permeability Through Caco-2 Cell Monolayers
Ethanol significantly increased the permeability of oxycodone, oxymorphone and atenolol in a concentration-dependent (1–5%) manner. The permeability of hydromorphone and metoprolol were not altered by ethanol. Th...
Drug Delivery Approaches in Addressing Clinical Pharmacology-Related Issues: Opportunities and Challenges
Various drug delivery approaches can be used to maximize therapeutic efficacy and minimize side effects, by impacting absorption, distribution, metabolism, and elimination (ADME) of a drug compound. For those drugs with...