Does Vitamin D Influence the Ovarian Reserve in Infertile Women-A Short Communication
Journal Title: Open Access Journal of Reproductive System and Sexual Disorders - Year 2019, Vol 2, Issue 2
Abstract
Calcium homeostasis and bone density are 2 important functions of Vitamin D in human beings. To mediate its biologic functions, it utilizes Vitamin D receptors, that are present mostly in calcium regulating tissues like the bone and parathyroid glands [1]. Still finding Vitamin D receptors within the reproductive tissues like the ovary, endometrium, testis. Hypothalamus along with pituitary has stimulated the study of Vitamin D’s role in human reproduction [1]. Previous studies showed that Vitamin D can change the antimullerian hormone (AMH) signaling, follicle stimulating hormone (FSH) sensitivity and progesterone (P) Production and release in human granulose cells as per Irani M and Merhi Z [1]. Moreover, recently Chu et al 2018 carried out a systematic review and meta-analysis in women who were undergoing assisted reproduction showed that women having enough Vitamin D had >odds of getting a live birth (odds ratio 1.33) as compared to those who had deficient Vitamin D levels [2]. Hence with the presence of Vitamin D deficiency world over within women of reproductive age, it is imperative to study the effect of Vitamin D deficiency on ovarian physiology. Based on this recent Shapiro et al. [3] conducted a retrospective analysis from their computer data to study the relationship of Vitamin D levels and parameters of ovarian reserve in a big cohort of infertile women. Since they had got an academically affiliated private fertility center where most of women presented with diminished ovarian reserve (DOR), they studied 457 women between 21 and 50yrs. They had baseline, Vitamin D, specifically 25hydroxy Vitamin D (25OH-D), AMH and FSH levels that had been measured within 90days of each other.
Authors and Affiliations
Kulvinder Kochar Kaur, Gautam Allahbadia, Mandeep Singh
Keywords
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- EP ID EP648363
- DOI 10.32474/OAJRSD.2019.02.000134
- Views 81
- Downloads 0
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