DOPAMINE D2 RECEPTOR GENE POLYMORPHISMS AND EXTERNALIZING BEHAVIORS IN CHILDREN AND ADOLESCENTS
Journal Title: INTERNATIONAL JOURNAL OF PURE MEDICAL RESEARCH - Year 2017, Vol 2, Issue 10
Abstract
Dopamine is involved in several cerebral physiological processes, and single nucleotide polymorphisms (SNP) in the dopamine D2 receptor gene (DRD2) have been associated with numerous neurological and mental disorders. The aim of this study was to evaluate the association between the SNPs c.957C>T (rs6277) and c.-585A> G (rs1799978) of the DRD2 gene and behavioral characteristics of children and adolescents based on an inventory of the Child Behavior Checklist (CBCL). Eighty-ve patients between 8 and 20 years old were assessed overall, and the presence of the T allele (C/T and T/T) polymorphism of DRD2 c.957C> T was found to be signicantly associated with the occurrence of deant and oppositional problems and with attention and hyperactivity problems. There were no associations detected with polymorphism DRD2 c.-585A> G. Specically, the presence of the T allele (C/T, T/T) in SNP c.957C>T was associated with difficulty in impulse control, self-control of emotions, and conduct adjustment, which can contribute to improving the identication of mental and behavioral phenotypes associated with gene expression.
Authors and Affiliations
Osmar Henrique Della Torre, Lúcia Arisaka Paes, Amilton dos Santos, Taciane Barbosa Henriques, Maricilda Palandi de Mello, Eloisa Helena Rubello Valler Celeri, Gil Guerra-Júnior, Paulo Dalgalarrondo
Keywords
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