Dose dependent Effect of Intrathecal Dexmedetomidine with Bupivacaine in Infraumblical Surgeries
Journal Title: IOSR Journal of Dental and Medical Sciences (IOSR-JDMS) - Year 2018, Vol 17, Issue 3
Abstract
Various intrathecal adjuvants are being used with local anesthetics for prolongation of intraoperative and postoperative analgesia. Dexmedetomidine (DMT), a highly selective alpha-2 adrenergic agonist is a new neuraxial adjuvant gaining popularity. The study included 60 ASA class I and II patients undergoing infra umbilical surgery under spinal anesthesia. The patients were randomly allocated into three groups (20 patients each).Each group recieved 4 µgm, 6µgm, and 8 µgm of DMT with 3 ml of bupivacaine respectively. The onset time to reach peak sensory and motor level, duration of sensory and motor block, duration of postoperative analgesia, hemodynamic changes, and side effects were recorded. Result -Onset of sensory and motor blocks were similar in all 3 groups. There was a significant and dose-dependent prolongation of duration of sensory block (190.7+/-21.37, 211.05+/-13, 238.15+/-21.53 min (p.00159<0.05) Duration of motor block (319+/-25.25, 350.42+/-16, 390.7+/-33.55 min p.000267<0.05 and duration of analgesia (442.8+/-34.96, 475.25+/-34.44, 611.58+/-35.46 min (p.0000001<0.05) with escalating doses of DMT. Conclusions: There is significant prolongation in duration of motor block, sensory block and analgesia without any significant adverse effect, with increasing doses of intrathecal DMT added to 0.5% bupivacaine
Authors and Affiliations
Sapna Singh, B L Mathur, Neena Rungta
Keywords
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- EP ID EP369875
- DOI 10.9790/0853-1703146872.
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