Dose Response Effect of Nitroglycerin on Cardiac Hemodynamic Functions and Myocardial Infarction in a Rat Model of Ischemia Reperfusion
Journal Title: The Egyptian Journal of Hospital Medicine - Year 2018, Vol 71, Issue 5
Abstract
<span>Background: </span><span>Millions of people suffer from acute coronary syndrome, angina, acute myocardial infarction (MI), or related illnesses. These patients are prescribed nitroglycerin (NG) for the management of these diseases. Accordingly, any risk associated with the use of nitroglycerin can potentially affect those people despite of the undeniable benefit in relieving acute angina. </span><span>Aim of the present work: </span><span>was to study the potential of treatment with 3 different doses of NG (25, 50, 100 mg/kg) to develop nitrate tolerance.<br /> </span><span>Materials and Methods</span><span>: 50 Male Albino rats were randomly divided into 2 main groups: sham group and ischemia/reperfusion (I/R) groups, which was further subdivided into 4 groups, Untreated group; NG 25, 50 and 100 mg groups; rats received nitroglycerin three times daily for 3 days before induction of ischemia reperfusion. the effect of NG on cardiac functions and infarction size and severity score were assessed. </span><span>Results: </span><span>Rats exposed to I/R exhibited a significant decrease </span><span>in their cardiac hemodynamic functions (↑ </span><span>left ventricular end diastolic pressure; </span><span>LVEDP and ↓dp/dt</span><span>max</span><span>) and development of a measurable cardiac infarction area. Regarding pretreatment with NG; NG 25 mg/kg improved cardiac functions and myocardial infarction size & severity score. NG 50 mg/kg significantly decreased myocardial contractility and increased myocardial infarction size. Meanwhile NG 100 mg/kg produced significant decrease in cardiac functions and significant increase in myocardial infarction size & severity score.<br /> </span><span>Conclusion</span><span>: NG pretreatment dose dependently decreased cardiac hemodynamic functions and increased myocardial infarction size & severity score in a rat model of ischemia reperfusion.<br /> </span>
Authors and Affiliations
Eman Helal
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