Dose-response relationship analysis of vigabatrin doses and their antinociceptive effects in the hot-plate test in mice.
Journal Title: Pharmacological Reports - Year 2008, Vol 60, Issue 3
Abstract
This study was aimed at determining the analgesic effects of vigabatrin (VGB, a newer antiepileptic drug) in the acute thermal pain model (hot-plate test) in mice. Linear regression analysis was used to evaluate a dose-response relationship between logarithms of VGB doses and their resultant maximum possible antinociceptive effects (MPAE) in the hot-plate test in mice. From the linear equation of dose-response relationship, doses of VGB that increased the antinociceptive effect by 15%, 20% and 25% were calculated and amounted in this study to 144, 383 and 1016 mg/kg, respectively. In conclusion, VGB in a dose-dependent manner produces the analgesic effects in mice in the hot-plate test. The method allowing for the calculation of doses of VGB increasing the antinociceptive effects by 15%, 20% and 25% can be readily adapted to preclinical studies because these values perfectly characterize the potency of antiepileptic drugs with respect to suppression of acute thermal pain in mice.
Authors and Affiliations
Jarogniew Luszczki, Stanisław Czuczwar
Keywords
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