Dose-response relationship analysis of vigabatrin doses and their antinociceptive effects in the hot-plate test in mice.
Journal Title: Pharmacological Reports - Year 2008, Vol 60, Issue 3
Abstract
This study was aimed at determining the analgesic effects of vigabatrin (VGB, a newer antiepileptic drug) in the acute thermal pain model (hot-plate test) in mice. Linear regression analysis was used to evaluate a dose-response relationship between logarithms of VGB doses and their resultant maximum possible antinociceptive effects (MPAE) in the hot-plate test in mice. From the linear equation of dose-response relationship, doses of VGB that increased the antinociceptive effect by 15%, 20% and 25% were calculated and amounted in this study to 144, 383 and 1016 mg/kg, respectively. In conclusion, VGB in a dose-dependent manner produces the analgesic effects in mice in the hot-plate test. The method allowing for the calculation of doses of VGB increasing the antinociceptive effects by 15%, 20% and 25% can be readily adapted to preclinical studies because these values perfectly characterize the potency of antiepileptic drugs with respect to suppression of acute thermal pain in mice.
Authors and Affiliations
Jarogniew Luszczki, Stanisław Czuczwar
Keywords
Related Articles
- EP ID EP96705
- DOI -
- Views 96
- Downloads 0
Abstracts of the ninth conference on Progress in Etiopathogenesis of Seizures.
Melatonin in experimental seizures and epilepsy.
Although melatonin is approved only for the treatment of jet-lag syndrome and some types of insomnia, clinical data suggest that it is effective in the adjunctive therapy of osteoporosis, cataract, sepsis, neurodegenerat...
Lipid peroxidation and antioxidant protection in patients during acute depressive episodes and in remission after fluoxetine treatment.
Increasing numbers of studies indicate that free radicals and their derivatives play a role in some neuropsychiatric disorders, such as depression. The aim of this study was to investigate the activities of antioxidant e...
Polyphenols as potential therapeutical agents against cardiovascular diseases.
Increasing evidence suggests that polyphenols from fruits, vegetables and beverages such as wine and tea may exert protective effects on the cardiovascular system. Indeed, research in the field of polyphenols points out...
Effects of low doses of intracerebroventricular 6-OHDA on the levels of monoaminergic neurotransmitters in rat brain structures.
The objective of this study was to determine the degree and specificity of noradrenergic lesions in different areas of the rat brain after intracerebroventricular administration of low doses of 6-hydroxydopamine (6-OHDA)...