Dose titration of concurrent use of two antihypertensives in a teritary care superspeciality hospital
Journal Title: INTERNATIONAL JOURNAL OF CURRENT RESEARCH - Year 2014, Vol 6, Issue 1
Abstract
Ramipril is an angiotensin converting enzyme (ACE) inhibitor and Metoprolol a β-adrenergic blocker used as antihypertensive. In this study we aimed to titrate the concurrent use of two most conventionally used antihypertensives. Objectives of this study were to evaluate the effect of regular intake of Ramipril and Metoprolol by patients with mild to moderate grade of hypertension, to adjust the dose and to educate the patients by providing patient counseling. In this multidose open label randomized block study, was conducted between March 2010 and November 2010 at CARE super specialty hospital, Hyderabad. A total of 60 patients were enrolled and were asked to have total of four visits including first screening visit, with 6 weeks interval between each visit. Study treatments included; Dose A (2.5mg Ramipril+25mg Metoprolol), Dose B (5mg Ramipril+50mg Metoprolol) and Dose C (10mg Ramipril+50mg Metoprolol) and patient counseling emphasizing on the role of diet, life style modification and regular exercise for management of hypertension. Blood pressure (B.P) was measured on every visit including the day of enrolment and the results were analyses from the data obtained. The study concluded that gradual up-gradation of the combination dose was useful in controlling hypertension. Along with it, patient counseling was found to be beneficial for the patients.
Authors and Affiliations
Padmavathi Devi KSKD, Raja Shekhar, S. , Umamaheshwara Rao, V. and Sushanta Kr. Das
Keywords
Related Articles
- EP ID EP405931
- DOI -
- Views 108
- Downloads 0
Association of serum uric acid with severity of osteoarthritis of knee
Aim: The objective of the study was to find out association between serum uric acid (UA) levels and severity of pain in different grades of osteoarthritis of knee (KOA) patients. Methods: After obtaining ethical clearan...
Role Of Mdct In Evaluation Of Proximal Tibia Fractures
Introduction: Proximal tibia articular fractures can be caused by motor vehicle accidents or bumper strike injuries ;however, sports injuries, falls, and other less violent trauma frequently produce them, especially in e...
Zika – The terror looms large over India
The infection, known as Zika fever, often causes no or only mild symptoms, similar to a very mild form of dengue fever. Zika may spread from a pregnant woman to the baby. This may result in microcephaly and other severe...
Co-Occurrence of os peroneum and accessory navicular bone in a foot: a rare presentation
Accessory ossicles most of the times found incidentally in the foot and they vary widely in their appearance, combinations and prevalence. Accessory ossicles are mostly asymptomatic but sometimes these may become symptom...
A rare case of mesocolic hernia causing intestinal obstruction Leading to perforation
Internal hernia may be either congenital or acquired. Its incidence has been reported to be 1-2%. Herniation may be persistent or intermittent. Internal hernia is a rare cause of small bowel obstruction with a reported i...