Dosimetric Comparison between Two Different Intensity Modulated Radiation Therapy and 3D-Conformal Radiation Therapy Planning Techniques for Carcinoma of Breast Following Conservative Surgery
Journal Title: Journal of Clinical and Diagnostic Research - Year 2018, Vol 12, Issue 10
Abstract
Abstract Introduction: The anatomy of the chest wall is curved which makes it quite complicated to plan radiation therapy for breast cancer. There are different techniques for delivering external beam radiation therapy. Therefore, it is essential to know the technique by which we can render a better treatment. Aim: To compare and analyse three different planning techniques namely Three Dimensional Conformal Radiation Therapy (3DCRT), two field Intensity Modulated Radiation Therapy (IMRT) and multiple field IMRT using dosimetric parameters. Materials and Methods: In this retrospective dosimetric study, we evaluated 10 breast cancer patients. For each patient, three plans namely 3DCRT, two field IMRT and multiple field IMRT (7 beams) were generated on the computed tomographic images using Oncentra Treatment Planning system. A dose of 50Gy in 25 fractions was prescribed to the Planning Target Volume (PTV). The plans were compared with each other on volume coverage (conformity and homogeneity) and organ-at-risk sparing. Paired t-test was used for identifying statistical differences between the plans. A significance level, p=5% or 0.05 was chosen. Results: The dose conformity was best by multiple field IMRT (p=0.0001). Both two field IMRT and multiple field IMRT provided more homogenous dose distribution with homogeneity index of 1.09±0.01 and 1.08±0.01 respectively when compared to 1.11±0.01 by 3DCRT (p=0.001 and 0.0001, respectively). D2 (dose received by 2% of the tumour volume), a measure of maximum dose was greater in 3DCRT. While dose to the critical organs was considerably less in both two field IMRT and 3DCRT than in multiple field IMRT, two field IMRT achieved lowest doses. Moreover, there was a substantial increase in the Monitor Units (MUs) for multiple field IMRT when compared with the other two techniques. Conclusion: Two field IMRT have the features intermediate of 3DCRT and multiple field IMRT. The two field IMRT is on the beneficial side with homogenous dose distribution in the target and less dose to the critical organs.
Authors and Affiliations
Michelle D’Almeida, Jyothi Nagesh, Ramya Balasubramanian, Srinidhi Gururajarao Chandraguthi, Sarath S Nair, Shreekripa . , Krishna Sharan
Keywords
Related Articles
- EP ID EP529714
- DOI 10.7860/JCDR/2018/31495.12073
- Views 43
- Downloads 0
Diagnosis of a Fatal Rickettsial Infection in a 44-Year-Old Male
ABSTRACT Rickettsial infections are an emerging public health concern in many parts of India with several undiagnosed or misdiagnosed cases. Despite its widespread prevalence in India, lack of suspicion, nonspecific sign...
Primary Ewings Sarcoma of Kidney: A Case Report
ABSTRACT Primary Ewings Sarcoma (EWS) of the kidney is a very rare tumour and very few cases have been reported till date. We present a case of a 36-year-old lady presenting to us with flank pain and haematuria, with a h...
Nonfunctional Cystic Hepatic Paraganglioma Mimicking Hydatid Cyst
An extra-adrenal pheochromocytoma is also known as a paraganglioma. We are reporting the case of a 68-year-old female patient with an extremely rare primary nonfunctioning hepatic paraganglioma without any clinical signs...
A Case of Limb Girdle Muscular Dystrophy Type 2A from India: Copy Number Variation Analysis using Targeted Amplicon Sequencing
ABSTRACT Limb Girdle Muscular Dystrophy-Type 2A (LGMD-2A) is an autosomal recessive disease caused due to mutation in the Calpain-3 (CAPN3) gene, leading to partial or total loss of protein. In India, LGMD-2A is the most...
Determinants of Job Satisfaction amongst Medical Officers of Primary Health Centre in Anand District, Gujarat, India
ABSTRACT Introduction: Dissatisfaction with job is invariably linked with decreased work performance. Discontent provider is more likely to face difficulty in caring for his patients and provide quality medical care. Thu...