Double Blind Placebo Controlled Study to Compare the Efficacy of Esmolol and Diltiazem in Attenuation of Pressor Response Due to Laryngoscopy and Endotracheal Intubation in Controlled Hypertensive Surgical Patients
Journal Title: International Journal of Contemporary Medical Research - Year 2016, Vol 3, Issue 1
Abstract
Introduction: Pressor response in the form of tachycardia and hypertension are well documented sequels of laryngoscopy and endotracheal intubation which is transient, highly variable and is generally well tolerated in healthy patients. In hypertensive patients this response is exaggerated. The aim of this study is to find a better alternative by comparing esmolol and diltiazem to attenuate the pressor response to laryngoscopy and intubation. Material and Methods: One hundred fifty hypertensive patients of either sex (ASA II), controlled on antihypertensive medications in 40-60 Year age range scheduled for routine surgical procedures were divided into 3 groups: Group A (10 ml of 5 % Dextrose), Group B (Esmolol 1.5 mg/Kg) and Group C (Diltiazem 0.2 mg/Kg). Heart rate, systolic blood pressure, diastolic blood pressure, mean arterial blood pressure and rate pressure product were noted at baseline level, at 1 min., 3min. and 5min after tracheal intubation. Results: When compared to control both esmolol and diltiazem showed a statistically significant attenuation of rise in systolic blood pressure, diastolic blood pressure, mean arterial blood pressure and rate pressure product. However Diltiazem failed to reduce rise in heart rate. Conclusion: Esmolol was found to be a better agent in attenuating the pressor response to laryngoscopy and intubation in these patients.
Authors and Affiliations
Syed Tariq Bukhari, Mohammad A Shah, Gazi P Ahmad Chiken, Yasir Bashir, Suhail A Shah, Humariya Heena, Nusrat Bashir, Abdul W Mir
Keywords
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