Double Blind Placebo Controlled Study to Compare the Efficacy of Esmolol and Diltiazem in Attenuation of Pressor Response Due to Laryngoscopy and Endotracheal Intubation in Controlled Hypertensive Surgical Patients
Journal Title: International Journal of Contemporary Medical Research - Year 2016, Vol 3, Issue 1
Abstract
Introduction: Pressor response in the form of tachycardia and hypertension are well documented sequels of laryngoscopy and endotracheal intubation which is transient, highly variable and is generally well tolerated in healthy patients. In hypertensive patients this response is exaggerated. The aim of this study is to find a better alternative by comparing esmolol and diltiazem to attenuate the pressor response to laryngoscopy and intubation. Material and Methods: One hundred fifty hypertensive patients of either sex (ASA II), controlled on antihypertensive medications in 40-60 Year age range scheduled for routine surgical procedures were divided into 3 groups: Group A (10 ml of 5 % Dextrose), Group B (Esmolol 1.5 mg/Kg) and Group C (Diltiazem 0.2 mg/Kg). Heart rate, systolic blood pressure, diastolic blood pressure, mean arterial blood pressure and rate pressure product were noted at baseline level, at 1 min., 3min. and 5min after tracheal intubation. Results: When compared to control both esmolol and diltiazem showed a statistically significant attenuation of rise in systolic blood pressure, diastolic blood pressure, mean arterial blood pressure and rate pressure product. However Diltiazem failed to reduce rise in heart rate. Conclusion: Esmolol was found to be a better agent in attenuating the pressor response to laryngoscopy and intubation in these patients.
Authors and Affiliations
Syed Tariq Bukhari, Mohammad A Shah, Gazi P Ahmad Chiken, Yasir Bashir, Suhail A Shah, Humariya Heena, Nusrat Bashir, Abdul W Mir
Keywords
Related Articles
- EP ID EP424567
- DOI -
- Views 91
- Downloads 0
Clinical Profile of Stroke among Young Adults
Introduction: Stroke was defined as rapidly developing clinical signs of focal,at times, global disturbance of cerebral function lasting for more than 24 hours or leading to death with no apparent cause other than vascul...
Diagnostic Utility of Immunohistochemistry in Lymphoma
Introduction: The pattern of distribution of lymphomas varies across different regions. This study conducted at a tertiary care hospital in North east India has taken into account immunhistochemmical findings and subclas...
Efficacy of Dexamethasone as an Adjuvant with Lignocaine- Adrenaline and Bupivacaine for Supraclavicular Brachial Plexus Block Versus Lignocaine-Adrenaline with Bupivacaine only
Introduction: Many adjuvants with local anesthetic have been used for brachial plexus block prolongation. Dexamethasone when added to local anesthetic, block prolongation with analgesic and anti inflammatory effects have...
Clinical Evaluations of Bowel Continence in Post Operative Patients of Distal Large Gut Anomalies and it’s Correlation with Anorectal Manometry
Introduction: Anorectal malformation is a common congenital anomaly. Posterior sagittal ano-recto-plasty (PSARP) is an established technique for repair of these anomalies. Many post operative children have defecation dis...
Laparoscopic Management of a Proximal Small Bowel Intussusception Secondary to a Rare Benign Neoplasm: A Case Report with Review of Literature
Introduction: Intussusception in adults is a rare entity in which there is telescoping of proximal bowel (intussusceptum) into the lumen of adjacent distal segment (intussuscepiens). Although a leading cause of intestina...