Doxorubicin hydrochloride. Determination in workplace air with high performance liquid chromatography

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Doxorubicin hydrochloride. Determination in workplace air with high performance liquid chromatography

Journal Title: Podstawy i Metody Oceny Środowiska Pracy - Year 2018, Vol 34, Issue 2

Abstract

This article presents a method for measuring doxorubicin hydrochloride in workplace air with HPLC with diode array detector (DAD). The method is based on adsorption inhalable fraction of doxorubicin hydrochloride aerosol on glass fiber filter, desperation with water, and chromatographic analysis. The analysis was performed in reverse phase (mobile phase – 0.05 mol/L hydrophosphate disodum and acetonitrile (65:35) with pH – 3 with 0.5 mL/L triethylamine) on C18 column. The measurement range was 0.06 – 1 μg/m3 for 4800-L air sample. The limit of detection (LOD) was 0,0005 μg/ml and the limit of quantification (LOQ) was 0,0015 μg /ml. The developed method of doxorubicin hydrochloride determination has been recorded as an analytical procedure (see appendix).<br/><br/>

Authors and Affiliations

Małgorzata Szewczyńska

Keywords

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EP ID EP346618
DOI 10.5604/01.3001.0012.1025
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