Dramatic Response to Ustekinumab Treatment in a Patient with Ankylosing Spondylitis and Crohn’s Disease and Anti-tumor Necrosis Factor-alpha Drug Induced Psoriasis
Journal Title: Turkish Journal of Osteoporosis - Year 2020, Vol 26, Issue 3
Abstract
Treatment with anti-tumour necrosis factor-alpha (anti-TNF-α) drugs provides significant improvements in many chronic inflammatory diseases with common pathogenesis, including Crohn’s disease, ankylosing spondylitis and psoriasis. However, during these treatments, paradoxically, cutaneous side effects such as psoriasis can be seen. Although its pathophysiology is well understood, it is thought that TNF-α blockade triggers locally excessive interferon-α production in predisposed subjects and causes psoriatic lesions. In this case report, we present a 50-year-old female patient with ankylosing spondylitis and Crohn’s disease who used adalimumab and then infliximab and developed psoriasiform lesions due to these drugs. Anti-TNF-α treatment was discontinued, and ustekinumab was started. Psoriasiform rashes improved; disease activity of ankylosing spondylitis and Crohn’s disease was suppressed. Ustekinumab may be a good option to manage ankylosing spondylitis and patients with Crohn’s disease who develop psoriasiform rashes due to anti-TNF-α drugs.
Authors and Affiliations
Sevilay Kılıç, Hatice Reşorlu, Alper Ekinci, Ayşe Selcen Bulut Keskin
Keywords
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- EP ID EP691613
- DOI 10.4274/tod.galenos.2020.71677
- Views 93
- Downloads 0
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