Drug interaction of boceprevir and amlodipine in a patient with hepatitis C: A cardiovascular follow-up
Journal Title: Journal of Microbiology and Infectious Diseases - Year 2015, Vol 5, Issue 1
Abstract
Boceprevir is a NS3/4A hepatitis C virus (HCV) protease inhibitor, used in combination with peginterferon and ribavirin to treat HCV. Boceprevir undergoes extensive metabolism via cytochrome P450-mediated oxidation and ketoreduction by cytosolic aldo-keto reductases. Amlodipine has been used for the treatment of patients with hypertension and also metabolised through cytochrome P450 pathway. Here, we presented a case of boceprevir and amlodipine interaction in a patient with chronic HCV and her echocardiography and electrocardiographic follow-up results. J Microbiol Infect Dis 2015;5(1): 32-35 Key words: Amlodipine, boceprevir, drug ınteraction
Authors and Affiliations
Çiğdem Kader, Hüseyin Ede, Ayşe Erbay, Ali Erbay
Keywords
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- EP ID EP127588
- DOI 10.5799/ahinjs.02.2015.01.0172
- Views 92
- Downloads 0
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