Drug interaction of boceprevir and amlodipine in a patient with hepatitis C: A cardiovascular follow-up

Journal Title: Journal of Microbiology and Infectious Diseases - Year 2015, Vol 5, Issue 1

Abstract

Boceprevir is a NS3/4A hepatitis C virus (HCV) protease inhibitor, used in combination with peginterferon and ribavirin to treat HCV. Boceprevir undergoes extensive metabolism via cytochrome P450-mediated oxidation and ketoreduction by cytosolic aldo-keto reductases. Amlodipine has been used for the treatment of patients with hypertension and also metabolised through cytochrome P450 pathway. Here, we presented a case of boceprevir and amlodipine interaction in a patient with chronic HCV and her echocardiography and electrocardiographic follow-up results. J Microbiol Infect Dis 2015;5(1): 32-35 Key words: Amlodipine, boceprevir, drug ınteraction

Authors and Affiliations

Çiğdem Kader, Hüseyin Ede, Ayşe Erbay, Ali Erbay

Keywords

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  • EP ID EP127588
  • DOI 10.5799/ahinjs.02.2015.01.0172
  • Views 94
  • Downloads 0

How To Cite

Çiğdem Kader, Hüseyin Ede, Ayşe Erbay, Ali Erbay (2015). Drug interaction of boceprevir and amlodipine in a patient with hepatitis C: A cardiovascular follow-up. Journal of Microbiology and Infectious Diseases, 5(1), 32-35. https://europub.co.uk/articles/-A-127588