Drug rashes in HIV patients
Journal Title: Αρχεία Ελληνικής Ιατρικής - Year 2006, Vol 23, Issue 6
Abstract
OBJECTIVE The multiple therapeutic means used in HIV infection induce side effects with variable intensity. Drug induced hypersensitivity reactions are common and potentially alter the therapeutic strategies. METHOD In a reference population of 1,096 HIV/AIDS patients skin reactions to medication were studied. RESULTS A total of 149 drug induced reactions were registered in 126 patients (11.5%). A diffuse maculopapular rush was most commonly seen (75.1%). Urticaria (10%), erythema multiforme (2%), Stevens-Johnson (3.3%) and Lyell's syndromes (2.7%) were also observed. Non-nucleoside analogue reverse transcriptase inhibitors (NNRTIs) induced 41 reactions in 327 patients (12.5%). Hypersensitivity to nucleoside analogue reverse transcriptase inhibitors (NRTIs) or protease inhibitors (PIs) was extremely rare. CONCLUSIONS Severe life-threatening side-effects to HIV medication are not rare and they are associated with drug category.
Authors and Affiliations
K. KYRIAZIS, V. PAPARIZOS, S. KOURKOUNTI, C. BOTSI, A. KATSAMBAS
Keywords
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