DRUG UTILIZATION PATTERN AND ADVERSE DRUG REACTION MONITORING IN URINARY TRACT INFECTION PATIENTS IN A TERTIARY CARE HOSPITAL
Journal Title: Journal of Drug Delivery and Therapeutics - Year 2015, Vol 5, Issue 6
Abstract
Background: Urinary tract infection is a key public health issue causing morbidity, especially in women population. This problem is further aggravated in pregnant women. Aims:This study was designed to evaluate the drug prescribing behaviour and adverse drug reaction monitoring in urinary tract infection patients in a tertiary care hospital. Materials and Methods:The present study was prospective, observational and carried out for four months, and done to assess the drug utilization pattern, adverse drug reactions (ADRs) and to identify the bacterial pathogens associated with UTI and their susceptibility to antibiotics.Results:A total of 327 female patients were evaluated, out of which 248 (75.84%) cases were symptomatic. The study reflected maximum of 50.46% UTI in the age group 21-30 years. Pathogens isolated after a urine culture were of both Gram positive 131 (40.07%) and Gram negative 196 (59.93%) type. The maximum incidence (45.80 %) occurred in last trimester of pregnancy. The most frequently prescribed antibiotic to the pregnant patients in our study was Nitrofurantoin, whereas Amoxicillin with Clavulanic acid was most frequently used in non pregnant cases. Most common ADRs reported with almost all classes of antibiotics was nausea and vomiting followed by vaginal irritation, skin rash and photosensitivity.Conclusion:To ensure appropriate therapy, current knowledge of the pathogenic organism and their antibiotic susceptibility pattern is mandatory, especially in cases of UTI with pregnancy.
DEVELOPMENT AND VALIDATION OF BIOANALYTICAL RP HPLC METHOD FOR THE ESTIMATION OF METOPROLOL TARTRATE IN RABBIT PLASMA AFTER TRANSDERMAL AND ORAL ADMINISTRATION: APPLICATION IN PHARMACOKINETIC STUDIES
A simple, specific, sensitive and rapid Reverse phase high performance liquid chromatographic (RP-HPLC) method has been developed and validated for the quantification of Metoprolol Tartrate in small volumes of rabbit pla...
A study to assess knowledge regarding fatty liver among bank employees working in selected banks at Mangaluru
Background: Fatty liver is closely associated with lifestyle. The bank employees have been often witnessed having junk food, coming home late and not engaged in any physical activity. Hence, an attempt has been made by t...
Noisomes: as novel vesicular drug delivery system
Target-specific drug-delivery systems for the administration of pharmaceutical compounds enable the localization of drugs to target sites within the body. The basic component of drug delivery systems is an appropriate c...
Preliminary phytochemical analysis, antimicrobial and antioxidant activity of Smilax zeylanica L. (Smilacaceae)
Objectives: Smilax zeylanica L. is a large, dioecious, scandent climbing shrub and an important medicinal plant belonging to the family Smilacaceae. The present study evaluates antimicrobial and antioxidant potential of...
POLYCYSTIC OVARY SYNDROME: PATHOGENESIS, TREATMENT AND SECONDARY ASSOCIATED DISEASES
Polycystic ovary syndrome (PCOS) is the most common endocrinopathy in women of reproductive age. It is characterized by hyperandrogenism, polycystic ovaries, and chronic anovulation along with insulin resistance, hyperin...