Drug utilization review and quality of life of biosimilars used in oncology in tertiary care hospital
Journal Title: International Journal of Research in Pharmacology & Pharmacotherapeutics (IJRPP) - Year 2019, Vol 8, Issue 3
Abstract
Background Biosimilars are considered to be one of the solutions to combat the substantially increasing costs of cancer treatment and its imminent introduction is expected to expand affordability worldwide. Biosimilars were developed as copies of original products that were themselves copies/better biosimilars of natural proteins. Objectives To review the drug utilization and Quality of life of biosimilars used in oncology patients. Methods It was a Hospital based observational, prospective study conducted by random selection of 50 patients. The data was collected regarding demographic details of the patient, chemotherapeutic drugs and administration,diagnosis, laboratory tests, mammography, PET (positron emission tomography), present complaints, history of patients and QOL of patients were also recorded. Patients were included in the study after obtaining verbal informed consent. Results and discussion In this prospective observational study the drug utilization review of biosimilars in various types of cancers were evaluated in a total of 50 patients.Among 50 patients who were treated with biosimilars and chemotherapeutics, 22% were male and 78% were female. The mean total scores for breast cancer, lung cancer, melanoma,NHL ,HL Urothelial carcinoma and colon cancer subjects at final visit increased compared to initial visit. This increment was highly significant statistically and the values were found to be [t= 30.9487, p= 0.0001] at 95% confidence interval. Conclusion All biosimilars showed improvement in symptoms &QOL scores. During the study period it was revealed that the most commonly used biosimilars for breast cancer was Trastuzumab, lung cancer durvalumab, melanoma & hodgkin’s lymphoma & urothelial carcinoma & colon cancer nivolumab, non-hodgkin’s lymphoma rituximab. The maximum improvement in QOL was obtained with nivolumab in urothelial cancer, melanoma &Hodgkin’s lymphoma patients.
Authors and Affiliations
Dr. Syeda Zaineb Kubra Hussaini
Keywords
Related Articles
- EP ID EP655359
- DOI -
- Views 58
- Downloads 0
Phytochemical Screening and GC-MS analysis of Ethanolic extract of TecomaStans (Family: Bignoniaceae) "Yellow Bell Flowers"
Flowers of TecomastansLinn popularly known as "yellow bell flowers" contain flavonoids. Flavonoids has been established to have antidepressant activity of the possible phytochemical components from the ethanolic extracts...
Epidemiology of Burn Injuries across Andhra Pradesh and the Practice of Systemic Antibiotic Prophylaxis
Background Trauma due to burns is a significant cause of injury worldwide. Ninety percent (90%) of the burn injuries are preventable but in a developing country like India, burn injuries continue to be a challenging prob...
Prescribing pattern of antimicrobial agents in patients with chronic suppurative otitis media at a tertiary care hospital
Background Chronic Suppurative Otitis Media (CSOM) is a serious healthcare concern worldwide, especially in developing countries like India despite the advances in healthcare facilities. India’s prevalence of CSOM is 7...
Epidemiology and Management of Panfacial Fractures and the Associated Injuries in Andhra Pradesh
Background Facial Trauma is considered as one of the leading causes of death among people who are aged under 40 years. Patients with facial fractures may be associated with a variety of injuries of other regions of the b...
COMPARATIVE STUDIES ON THE ANTIMICROBIAL ACTIVITY OF SELECTED SPECIES
In the present study, a total of twelve extracts of four spices namely cumin, mustard, fenugreek and asafoetida extracted with two solvents such as ethyl alcohol and ethyl acetate were evaluated for their antibacterial...