Drugs inhibiting the quorum-sensing of bacteria Staphylococcus aureus
Journal Title: Здоров`я дитини - Year 2019, Vol 14, Issue 3
Abstract
The scientific review presents data on the functioning of the quorum-sensing systems Agr and RAP/TRAP of Staphylococcus aureus bacteria. The paper gives the characteristics of medications inhibiting the export of AIP from a bacterial cell, the activity of histidine kinase AgrC, the expression and functional activity of AgrA, the expression of the RNAIII transcript of Staphylococcus aureus bacteria. It is suggested that the drugs developed to inhibit the activity of the mechanisms of the quorum sensing of Staphylococcus aureus bacteria will take a worthy place in anti-staphylococcal therapy.
Authors and Affiliations
A. E. Abaturov, Т. А. Kryuchko
Keywords
Related Articles
- EP ID EP577123
- DOI 10.22141/2224-0551.14.3.2019.168803
- Views 104
- Downloads 0
Herpes virus 6 hepatitis in an infant
The article presents a clinical observation of 1-year old child diagnosed with hepatitis in the structure of reactivated form of herpes virus type 6 infection. There was a significant increase in transaminase level with...
Informativeness of X-Ray and Ultrasound Techniques in the Diagnosis of Reactive Arthritis in Children
Background. Reactive arthritis is an important problem in pediatrics, which is associated with its highest specific weight (41–56 %) in the structure of the joint pathology in children. The importance of the problem is a...
State of Vegetative Homeostasis in Children with Anthracycline-Induced Cardiomyopathy
The paper presents the results of investigation of the autonomic nervous system in children with acute lymphoblastic leukemia, in whom as a result of protocol chemotherapy with anthracycline antibiotics application, toxi...
Side Effects of Basic Therapy in Children with Allergic Asthma
Objective — to detect side effects of basic therapy in children with allergic bronchial asthma (BA). Materials and Methods. The study involved 224 children with allergic BA aged 6 to 17 years, with evaluation of homocyst...
Lyme disease. Pediatric Aspects (II Part)
Up to 25 % of all patients with Lyme borreliosis — children aged 5–9 years. In children also have three clinical and pathogenetic stages of Lyme disease. Typical sign of borreliosis — erythema ≥ 5 cm in diameter, develop...