DRY POWDER INHALER; SPECIAL EMPHASIS TO FORMULATION, DEVICES, CHARACTERIZATION & PROCESS VALIDATION PROTOCOL: A REVIEW
Journal Title: Journal of Drug Delivery and Therapeutics - Year 2017, Vol 7, Issue 3
Abstract
The therapy was carried out by inhalation of medicinal plants to cure illness of respiratory tract by ancient people. A wide range of dry powder inhaler devices are presently available on the market to convey drugs into lungs with a view to capitalize on drug delivery with low variability. Drug powder inhalers also face copious clinical challenges, particularly related to capricious patient factors such as age, clinical condition and inspiratory flow. Due to the drug formulation and the design of devices, different drug powder inhalers do not demonstrate the same performance and manufacturers are taking an assortment of device design approaches. The characteristics of an ideal drug powder inhaler, current innovations in powder formulation and device design are not unanimously unswerving in terms of dose variability, clinical efficacy, user friendliness and economy. Particle Size of active pharmaceutical ingredient must be present in size range about 1-10 μm which also assurance that the patient gets the same dose every time at dissimilar airflow rate. Drug powder inhaler are formulated using four types of formulation strategies such as; Carrier free, Drug carrier, Drug additive, Drug carrier additive. Lung deposition study is accomplished by ‘Twin Stage Impingner’. The interior breath gadget is vital in accomplishing adequate transference of breathed in medication to lung which fundamentally grouped in view of measurements sort into single-unit and multi-dosage stores.
Authors and Affiliations
Diwaker Dadrwal
Keywords
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- EP ID EP295511
- DOI 10.22270/jddt.v7i3.1448
- Views 75
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