Dual Glory in Regenerative Endodontics
Journal Title: IOSR Journal of Dental and Medical Sciences (IOSR-JDMS) - Year 2018, Vol 17, Issue 12
Abstract
Traditionally, apexification has been the mode of treatment for immature permanent teeth that have lost pulp vitality. Since tissue engineering cannot be attained with apexification, a novel technique called regenerative endodontic was developed. Regenerative endodontic has been proposed to replace damaged and underdeveloped tooth structure with normal pulp- dentine tissue by providing a natural ECM mimicking environment, stem cells signaling molecules and scaffolds. In addition, clinical success of regenerative endodontic treatment can be evidenced by absence of signs and symptoms, no bony pathology, a disinfected pulp and maturation of root dentine in length and thickness. The construction of biomimetic microenvironment of pulp dentine- tissueis a key component of tissue engineering based regenerative endodontic. The biomimetic microenvironment are composed of synthetic nano scaled polymeric fiber structure that mimics native pulp extracellular matrix and functions as a scaffold of pulp dentine tissue complex and recruit pluripotent stem cells from the vicinity of the apex. This review focuses on the combined benefits of electronspun nanofibers and development and application of biomimetic microenvironment of pulp – dentine tissue along with recent progress in endodontic particularly encouraging regenerative outcomes achieved by evoked bleeding therapy in treatment of necrotic immature permanent teeth.
Authors and Affiliations
Dr. Reshma Achu Joseph BDS, Dr. Preethee Thomas MDS
Keywords
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- EP ID EP421618
- DOI 10.9790/0853-1712030106.
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