DUBIOUS ANTI-OBESITY AGENT HCA FROM GARCINIA: A SYSTEMATIC REVIEW
Journal Title: International Journal of Pharmacy and Pharmaceutical Sciences - Year 2015, Vol 7, Issue 7
Abstract
Obesity is a complex disorder of appetite regulation and energy metabolism controlled by specific biological factors. Whenever prevention fails, medicinal treatment of obesity may become an obligation and it is more fruitful when we can acquire the medicinal treatment directly from nature, which is more preferred and healthier rather than going for chemical and surgical treatment. Alternatively, inhibition of carbohydrate to fatty acid conversion reaction can lead to obesity control. This can be done by assay of Hydroxycitric acid [(-)-HCA], which inhibits the formation of ATP-citrate lyase, responsible for lipogenesis. HCA is a derivative of citric acid and found in Garcinia fruit as the principal acid. Many in vitro and in vivo studies have demonstrated that (-)-HCA suppresses the de novo fatty acid synthesis and lipogenesis. However, results from clinical studies showed both negative and positive anti obesity effects of (-)-HCA. In this review paper an attempt has been made to explore and give an insight of (-)-HCA taking account of the literature coverage on speckled topics: Its discovery, properties, extraction and estimation and its significance of role in anti-obesity activity.
Authors and Affiliations
Ankur Gogoi, Nabajyoti Gogoi, Bijoy Neog
Keywords
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