Dynamic bubble tensiometry as a useful tool for assessment of physicochemical interactions of liposomal drug carriers with respiratory tract
Journal Title: Challenges of Modern Technology - Year 2015, Vol 6, Issue 4
Abstract
This article presents an experimental investigation of physicochemical interactions of novel liposomal drug carriers intended for inhalation with model lung surfactant system. The research was done with the use of maximum bubble pressure (MBP) method to measure changes of dynamic surface tension of pulmonary surfactant system after contact with liposomal colloids made of lecithin and lecithin/cholesterol (3:1 w/w) before and after 5 and 10 minutes of nebulisation by pneumatic nebulizer. What is important to point, MBP method allows the discussion of measured phenomena with reference to the time scales characteristic for the changes of alveolar surface area during the breathing cycle. Obtained results may have a potential application during design and development of new therapeutic liposomal formulations for treatment of respiratory as well as systemic diseases.
Authors and Affiliations
Katarzyna Kramek-Romanowska, Tomasz Sosnowski
Keywords
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