Dynamics of Blood Pressure During the Development of Neuroleptic Cardiomyopathy
Journal Title: Advancements in Cardiovascular Research - Year 2018, Vol 1, Issue 2
Abstract
Neuroleptic cardiomyopathy (NCMP) is one of the most serious vitally dangerous complications of antipsychotic therapy [1-7], due to the side cardiotoxic effect of Antipsychotics (AP) [1,2,4,6-9]. The disease belongs to the secondary specific toxic (metabolic) dilated cardiomyopathies [1,3,10,11]. Is characterized by diffuse myocardial lesions, a sharp decrease in its contractile function and, as a consequence, development of chronic heart failure [3-6,12]. In its development NCMP passes three clinical stages: I - latent, II - deployed (manifesting) and III - terminal [3,13]. Many aspects of the pathogenesis, morphology, clinic and diagnosis of NCMP are still almost completely unexplored. The study of various clinic aspects of Neuroleptic Cardiomyopathy (NCMP) associated with the side cardiotoxic effect of Antipsychotics (AP) is actual. With the purpose to track dynamics of the Blood Pressure (BP) in the process of development of NCMP data about 78 died patients with schizophrenia (men - 53, women - 25) in whom NCMP is found on autopsy were retrospectively analyzed. At the age of 50 years were 43 persons, 44 died in the first stage of the disease, 12 - in the second one, 22 - in the third one. The conducted research allows to draw the following conclusions: a) Frequency of this or that option the AP in all stages of NCMP doesn’t depend on the age of patients.b) In a latent stage significantly prevail hypo and a normotony.c) In the developed stage steadily normal and labile BP with a tendency to moderate Arterial Hypertension (AH) are equally common.d) In the terminal stage of NCMP at ¼ patients is observed moderate AH and at 13,6% of patients the expressed stable AH.e) As a whole, according to own data, in the case of NCMP the frequency of AH is 37.2%.f ) Fluctuations of frequency of occurrence of this or level of BP are connected with various side effects of the AP used in the treatment of schizophrenia.
Authors and Affiliations
Volkov VP
Keywords
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- EP ID EP586156
- DOI 10.32474/ACR.2018.01.000110
- Views 60
- Downloads 0
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Dynamics of Blood Pressure During the Development of Neuroleptic Cardiomyopathy
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