Dynamics of cytokines level under the influence of lyophilized dialysate of leucocytes (Immodin) on the background of allergen-specific immunotherapy (ASIT) by pollene allergens in patients with pollinosis
Journal Title: Медичні перспективи - Year 2018, Vol 23, Issue 1
Abstract
The analysis of IL-4, INF-γ has been performed on the background of lyophilized dialysate of leucocytes (Immodin) in the course of the ASIT with pollen allergens among patients with pollinosis. 104 people of both genders were examined, average age was 34.3±1.0 years. All patients took the ASIT course before. It is denoted that prior to treatment half of the patients with hay fever (n=58 (55.8±4.9)%) had blood IL-4 level above the norm. The level of INF-γ in blood serum, in contrast, was lower and beyond the reference range. After preseasonal ASIT under the influence of lyophilized dialysate of leukocyte (Immodin) a significant decrease of IL-4 content in blood serum comparing to initial level – by 1.7 times or 40.2% (p<0.001) is observed. IL-4 content in blood serum of the main group after treatment was lower by 32.0%, comparing to the control group (p<0.001). IFN-γ level increased by 2.4 times among patients of the main group and by 1,9 times among patients of the control group. Hence, in presence of comparable levels of INF-γ before treatment in both groups, under the influence of ASIT the INF-γ concentration in blood serum in the main group is 33.9% higher than in control group. Studies indicate that ASIT effects on Th2 inhibitors, disenabling its activity, although under the influence of Immodin it proceeds reliably more efficiently already after the first course.
Authors and Affiliations
Ye. Koretskaia
Keywords
Related Articles
- EP ID EP298669
- DOI 10.26641/2307-0404.2018.1(part1).127241
- Views 117
- Downloads 0
The influence of adequate drug therapy on the clinical symptoms and level of serum amyloid A in patients with chronic obstructive pulmonary disease
The aim of our research was to study the dynamics of the level of SAA in COPD patients in the stable phase of the pathological process against the background of basic therapy. We studied 37 stable COPD patients with II-I...
Зарубежные статьи как фактор роста фальсификаций научных публикаций и снижения наукометрических показателей организаций
Ряд наказів Міністерства освіти і науки України стимулюють вчених публікувати свої статті за кордоном, але не вказують критерії вибору рекомендованих журналів. У результаті автори обирають найпростіший спосіб і розміщую...
Pneumonia in patients on the background of blood cancer
Problematic issues of etiologic diagnosis and treatment of community-acquired and nosocomial pneumonia are being studied actively. At the same time specific features of pneumonia in patients with severe immune defects, a...
Гигиеническая оценка комплексного поступления биотических и абиотических металлов в организм детей в условиях техногенно загрязненных территорий
Рассчитана суммарная суточная нагрузка и вклад разных путей поступления свинца в организм детей в условиях промышленных и контрольного района. Изучение комплексного поступления металла в детский организм с воздухом, вод...
Non-Hodgkin's lymphoma in the practice of the family doctor (clinical observation)
There is presented a clinical observation on the problem of establishing an oncological diagnosis by a family doctor, the route to a doctor-oncologist for specific treatment with subsequent work in the brigade team and m...