Dynamics of cytokines level under the influence of lyophilized dialysate of leucocytes (Immodin) on the background of allergen-specific immunotherapy (ASIT) by pollene allergens in patients with pollinosis

Journal Title: Медичні перспективи - Year 2018, Vol 23, Issue 1

Abstract

The analysis of IL-4, INF-γ has been performed on the background of lyophilized dialysate of leu­co­cytes (Immodin) in the course of the ASIT with pollen allergens among patients with pollinosis. 104 people of both gen­ders were examined, average age was 34.3±1.0 years. All patients took the ASIT course before. It is denoted that prior to treatment half of the patients with hay fever (n=58 (55.8±4.9)%) had blood IL-4 level above the norm. The level of INF-γ in blood serum, in contrast, was lower and beyond the reference range. After preseasonal ASIT under the influence of lyophilized dialysate of leukocyte (Immodin) a significant decrease of IL-4 content in blood serum comparing to initial level – by 1.7 times or 40.2% (p<0.001) is observed. IL-4 content in blood serum of the main group after treatment was lower by 32.0%, comparing to the control group (p<0.001). IFN-γ level increased by 2.4 times among patients of the main group and by 1,9 times among patients of the control group. Hence, in presence of com­pa­rable levels of INF-γ before treatment in both groups, under the influence of ASIT the INF-γ concentration in blood serum in the main group is 33.9% higher than in control group. Studies indicate that ASIT effects on Th2 inhibitors, di­senabling its activity, although under the influence of Immodin it proceeds reliably more efficiently already after the first course.

Authors and Affiliations

Ye. Koretskaia

Keywords

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  • EP ID EP298669
  • DOI 10.26641/2307-0404.2018.1(part1).127241
  • Views 117
  • Downloads 0

How To Cite

Ye. Koretskaia (2018). Dynamics of cytokines level under the influence of lyophilized dialysate of leucocytes (Immodin) on the background of allergen-specific immunotherapy (ASIT) by pollene allergens in patients with pollinosis. Медичні перспективи, 23(1), 77-82. https://europub.co.uk/articles/-A-298669