Dysfunctional labor and myometrial lactic acidosis.
Journal Title: Obstetrics & Gynecology - Year 2004, Vol 103, Issue 4
Abstract
OBJECTIVE: Inefficient uterine contractions are the most common cause ofpoor progress in labor. The global increase in cesarean delivery rate is a cause of considerable concern,and the greatest reason for increase is the result of failure to progress in labor. Following in vitrostudies that showed acidification could depress uterine contraction, we hypothesized that it could contributeto dysfunctional labors. METHODS: A blood sample was taken from the lower segment of the uterus fromwomen having a cesarean delivery, either electively or as a result of dysfunctional labor, and from thosehaving a normal labor. This blood sample was analyzed for pH, O(2) saturation, and lactate levels. Contractionwas recorded in myometrial strips, taken from women having elective cesarean delivery, at the pH of normallyand dysfunctionally contracting uteri. RESULTS: The pH of myometrial capillary blood from women havinga dysfunctional labor was significantly lower (7.35) than that from women having elective cesarean delivery(7.49) or cesarean delivery with normal contractions, with (7.47) or without (7.48) oxytocin (P
Authors and Affiliations
Siobhan Quenby, Sue J Pierce, Sara Brigham, Susan Wray
Keywords
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