Dyslipidemia in HIV positive patients on first line antiretroviral therapy
Journal Title: MedPulse -International Medical Journal - Year 2017, Vol 4, Issue 1
Abstract
Background: Abnormalities of lipid metabolism are common in human immunodeficiency virus (HIV)-infected patients and tend to be accentuated in those receiving highly active antiretroviral therapy (HAART). However, data on lipid profile of treatmentnaïve. HIV-infected patients in India are limited. So, the study was conducted to describe the pattern of lipid profile among treatmentnaive HIV-I positive patients and changes following HAART initiation in a tertiary care center. Methods: An observational prospective study was conducted on 120 normotensive, non-diabetic and non-obese, treatment-naive HIV-infected patients, out of which 65 were men and 55were women of age more than18 years, after applying appropriate inclusion and exclusion criterias. The study was carried out at ART center, in our tertiary care center for a period of 2 years from Dec 2012 to Nov 2014. HIV-I treatment naïve patients were put on different first line ART regimen according to NACO guidelines. Fasting lipid profiles were analyzed enzymatically. Values of lipid parameter were retrieved at the initiation of HAART then patients were followed after 3 and 6 months of HAART therapy. Results The study concluded that there was significant change in the lipid parameters following initiation of HAART, there was increase in mean TC,TG and LDL-C values at 3 months and further increase at 6 months with statistically highly significant P value(< 0.001). At the end of 6 month compared to baseline there was highly significant change in Triglycerides(139.33±23.82 to 145.77±24.42), TC(147.11±28.36 to 153.77 ± 28.74) and LDL (92.55 ± 11.94 to 98.11 ± 12.94) respectively , P value (< 0.001 ). There was no statistical difference in HDL value at the end of 3 month [p value (0.684)] as compared to baseline value, but at the end of 6 month it significantly changes 41.22 ± 2.38 to 38.55 ± 2.69 p value (< 0.001). Conclusions: With the use of first-line antiretroviral therapy regimens were associated with raised total cholesterol, LDL-cholesterol, and triglycerides, an established atherogenic lipid profiles Therefore we recommend that Lipid profiles should be performed at baseline before commencement of antiretroviral therapy and then periodically through treatment follow-up to monitor any rising trends .Lipid profile results can therefore be a good index for disease progression, intervention and management of HIV patients.
Authors and Affiliations
R N Salame, P L Patil
Keywords
Related Articles
- EP ID EP175957
- DOI -
- Views 122
- Downloads 0
Clinical profile of pulmonary tuberculosis in HIV patients
Background: Mycobacterium tuberculosis infection is very common in HIV patients. 120 cases of HIV-positive cases were screened for TB who were clinically diagnosed as Pulmonary Tuberculosis during the study period from J...
Transabdominal assisted ICD insertion minimise the malposition of tubes our experience compared with standard technique
Background: Tube thoracostomy is widely used throughout the medical, surgical, and critical care specialities. It is generally used to drain pleural collections either as elective or emergency. Complications resulting fr...
Prevalence of inguinal hernia in Indian population: a retrospective study
Introduction: Inguinal hernias are the most common form of abdominal wall hernias. The incidence of inguinal hernia is unknown, but about 500,000 cases come to medical attention each year. The data on primary and recurre...
Evaluation of thyroid lesions by fine needle aspiration cytology in a tertiary hospital – A one year retrospective study of 241 cases
Background: In the past 5 or 6 decades FNAC has been increasingly used for investigation of thyroid cases. Like any other organ, FNAC in thyroid is primarily performed to distinguish benign and malignant lesions. Our stu...
A study of various MRI findings in patients with extra-pulmonary tuberculosis at tertiary health care centre
Background: In the era before the human immunodeficiency virus (HIV) pandemic, and in studies involving immunocompetent adults, it has been observed that EPTB constituted about 15 to 20 per cent of all cases of TB Aims a...