Dyslipidemia in Patients of Psoriasis
Journal Title: Journal of Medical Science And clinical Research - Year 2015, Vol 3, Issue 2
Abstract
Background: Psoriasis is a common and recurrent proliferative inflammatory skin disease that has been associated with abnormal plasma lipid metabolism. The high prevalence of atherosclerosis has been reported in psoriatic patients. The aim of our work was to evaluate the development of dyslipidemia in psoriasis and to look for a correlation between their levels and worsening of disease. Methods: We evaluated the fasting lipid profile in 300 clinically diagnosed psoriasis patients (Group II) which were further grouped as 200 plain psoriasis (Group IIA) and 100 psoriasis with mixed complications (Group IIB) and 200 age and gender matched healthy subjects as the controls(Group I). Result: Patient presented risk changes in lipid profile, serum total cholesterol and LDL- cholesterol were found to be significantly increased(P<0.01) while there is no significant difference in triglyceride, VLDLcholesterol, HDL-cholesterol levels in Group IIB psoriasis patients with mixed complications than in Group IIA plain psoriasis patients. Conclusion: Our data suggests that high serum lipid profile level especially. Total cholesterol and LDLcholesterol is significantly more common in psoriasis and must be considered as a group at high risk for cardiovascular accidents(CVA). It may be useful to do early screening and treatment of hyperlipidemia in psoriasis to prevent the atherosclerosis and its complications.
Authors and Affiliations
B. K. Agrawal
Keywords
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