Dysregulation of the mTOR signaling pathway in the pathogenesis of autism spectrum disorders
Journal Title: Advances in Hygiene and Experimental Medicine - Year 2014, Vol 68, Issue
Abstract
Mammalian target of rapamycin (mTor) plays multiple role in central nervous system and is involved in regulation of cell viability, differentiation, transcription, translation, protein degradation, actin cytoskeletal organization and autophagy. Recent experimental and clinical studies reveal that disturbances of mTOR signaling are involved in the pathogenesis of autism spectrum disorders (ASD). This article reviews current data on the alteration in the mTOR transduction cascade, which may contribute to common neurobehavioral disorders typical for ASD. Moreover, the results of the latest experimental studies on the potential of mTOR inhibitors for the treatment of ASD are reviewed.
Authors and Affiliations
Bożena Gabryel, Agata Kapałka, Wojciech Sobczyk, Krzysztof Łabuzek, Agnieszka Gawęda, Małgorzata Janas-Kozik
Keywords
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