Early Diagnosis of Smear Negative Pulmonary Tuberculosis: A Two Year Study from Tertiary Care Center
Journal Title: International Journal of Contemporary Medical Research - Year 2018, Vol 5, Issue 2
Abstract
Introduction: Globally pulmonary tuberculosis as well as extra-pulmonary tuberculosis is a major public health issue, all age groups are at high risk to acquire infection. Multidrug resistant (MDR) and extensively-drug resistant (XDR) cases are increasing day by day, which is an alarm for the Government organization to improve the control program. Smear negative pulmonary tuberculosis (SNPT) is also an issue, which can be solved by using a Line probe assay. Success of any control program depend on early diagnosis and proper treatment, which will help to control transmission of disease in society. Aim of the study was to evaluate the efficacy of LPA in diagnosis of smear negative pulmonary tuberculosis cases and to detect mono-resistance and multidrug resistant. Material and Methods: This was a laboratory based observational study, which were conducted in department of microbiology, IGIMS, Patna and TBDC, Agamkuan, Patna, for the period of two years. Sputum specimens were collected from clinically suspected cases of pulmonary tuberculosis. Smear negative suspects were included in study, which were subjected to culture and LPA. Results: A total of 3729 sputum specimens were collected from suspected cases of PTB, which were subjected to sputum smear microscopy. A total of, 1611 smear negative samples were included in study, which were subjected to LPA and culture. Out of these, 904 (56%) were positive using culture and/or LPA, and 707 (44%) were negative by both diagnostic tests. Whereas in diagnosed cases of PTB using LPA, 558 samples were sensitive to rifampicin and isoniazid, and 195 samples were resistant to rifampicin and/or isoniazid. Conclusion: It has been seen that SNPT cases were increasing day by days, therefore LPA can be a reliable diagnostic tool to overcome these issue, which can reduce the treatment delay and transmission. However, culture must be followed in diagnosis of TB along with other test.
Authors and Affiliations
Rohit Kumar, Rakesh Kumar, Shivendra Kumar Shahi, Swati Salila, Shailesh Kumar, Balkrishna Mishra
Keywords
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