Ebolavirus and Haemorrhagic Syndrome
Journal Title: Sultan Qaboos University Medical Journal - Year 2015, Vol 15, Issue 2
Abstract
Te Ebola virus is a highly virulent, single-stranded ribonucleic acid virus which affects both humans and apes and has fast become one of the world’s most feared pathogens. Te virus induces acute fever and death, with haemorrhagic syndrome occurring in up to 90% of patients. Te known species within the genus Ebolavirus are Bundibugyo, Sudan, Zaïre, Reston and Taï Forest. Although endemic in Africa, Ebola has caused worldwide anxiety due to media hype and concerns about its international spread, including through bioterrorism. Te high fatality rate is attributed to unavailability of a standard treatment regimen or vaccine. Te disease is frightening since it is characterised by rapid immune suppression and systemic inflammatory response, causing multi-organ and system failure, shock and often death. Currently, disease management is largely supportive, with containment efforts geared towards mitigating the spread of the virus. Tis review describes the classifcation, morphology, infective process, natural ecology, transmission, epidemic patterns, diagnosis, clinical features and immunology of Ebola, including management and epidemic containment strategies.
Authors and Affiliations
Gerald A. Matua| Department of Fundamentals & Administration, College of Nursing, Sultan Qaboos University, Muscat, Oman, Dirk M. Van der Wal| Department of Health Studies, College of Human Sciences, University of South Africa, Pretoria, South Africa, Rozzano C. Locsin| Christine E. Lynn College of Nursing, Florida Atlantic University, Boca Raton, Florida, USA
Keywords
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