Edaravone Leads To Increased Internal Luminal Vascular Circumference Following Subarachnoid Hemorrhage in An Animal Model of Vasospasm
Journal Title: Journal of Neurological Sciences-Turkish - Year 2012, Vol 29, Issue 4
Abstract
Purpose: Cerebral vasospasm is the leading cause of morbidity and mortality following subarachnoid hemorrhage. Although a number of factors have been examined in clinical and experimental studies, the agent(s) responsible for developing and diminishing vasospasm remain poorly understood. Here, the role of edaravone, an antioxidant agent, was evaluated for its ability to diminish vasospasm in an animal model of subarachnoid hemorrhage. Materials and Methods: A rat basilar artery subarachnoid hemorrhage model was used. Rats were divided into three groups: sham (n=7; Group 1), subarachnoid hemorrhage (n=7 Group 2), and subarachnoid hemorrhage plus edaravone (4 mg/kg intraperitoneally, n=7; Group 3). At the end of the seventh day, the rats were sacrificed, their brains were removed, and sections were taken from the basilar artery. These were examined using a light microscope, comparing the internal luminal circumference of the basilar artery of each group. Results: The circumference was largest in Group 1, followed by Group 3 and then Group 2. That of Group 3 was 2% higher than that of Group 2, but this difference was not statistically significant. Conclusion: This animal model for vasospasm suggests that edaravone helps enlarge internal luminal circumference following vasospasm caused by subarachnoid hemorrhage. It may do this by blocking lipid peroxidation and thereby reducing the effects of oxyhemoglobin and reactive oxygen species.
Authors and Affiliations
Mesut METE, Fusun OZER, Yusuf DURANSOY, Umit KOCAMAN, Ismail ORAN, Eren DEMIRTAS, Mehmet SELCUKI
Rat Bone Marrow Stromal Cells Derived Neural Stem Cell-Like Cells Could Differentiate Into Functional Schwann Cell-Like Cells In Vitro
Objective: To induce neural stem cell (NSC)-like cells derived from rat bone marrow stromal cells (BMSCs) into functional Schwann cell (SC)-like cells. Methods: In this study, rat BMSCs were cultured, identified a...
The Role of Thrombocyte Activation on Early Brain Injury in Experimental Subarachnoid Hemorrhage Model
Aim: Thrombocyte activation is one of the mechanisms blamed for emerging of early brain injury(EBI) soon after subarachnoid hemorrhage(SAH). It is wondered by researching to what extend neuron injury is prevented by maki...
A Case of Epidural Lipomatosis With Lumbar Canal Stenosis
Objective: Idiopathic symptomatic spinal epidural lipomatosis is not a common clinical condition. There are a few cases reported in the literature discussing the magnetic resonance imaging (MRI) findings of epidural lipo...
Cognitive Impairment In Relapsing Remitting Multiple Sclerosis Patients
The purpose of this study is to evaluate the cognitive functions in cases with relapsing remitting MS during the period in which the physical disability is seen in a lower level, as well as to examine the level and predo...
Serebral sinĂ¼s trombozu