Edaravone Protects against Vascular Oxidative Damage Induced by AAPH in Chick Embryo
Journal Title: International Journal of Pharmaceutical Sciences and Developmental Research - Year 2016, Vol 2, Issue 1
Abstract
Background: Edaravone (Eda) is a free-radical scavenger which is used in treating stroke, cerebral hemorrhage and some other diseases in clinic. However, it’s antioxygenation during development is still unknown. Method: An oxidative damage model was established in chick embryo by using a generator of free radicals, 2,2’-azobis[2-methylpropionamidine] dihydrochloride (AAPH). The mortality rate and embryo’s weight were measured to detect whether retarded growth happened. In order to observe the blood vessels, the yolk-sac blood vessels and CAM blood vessels density were observed. The malondialdehyde (MDA) content and superoxide dismutase (SOD) enzymatic activity were detected to evaluate the oxidative damage in the chick embryo.
Authors and Affiliations
Wan Xin, Luo Meng-Xun, Jie Chong, Wu Tong, Yu Gui-Yuan, Li Yi-Fang, He Rong-Rong, Kurihara Hiroshi
Keywords
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- EP ID EP555595
- DOI 10.17352/ijpsdr.000007
- Views 56
- Downloads 0
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